BDBM50395272 CHEMBL1231206

SMILES Cc1ccc(cn1)c2ccc3c(n2)ccc4c3c5c(s4)C(=O)N[C@@H](CN5)C

InChI Key InChIKey=CMWRPDHVGMHLSZ-UHFFFAOYSA-N

Data  2 KI  20 IC50  1 Kd

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 23 hits for monomerid = 50395272   

TargetMAP kinase-activated protein kinase 2(Human)
Hefei University of Technology

Curated by ChEMBL
LigandPNGBDBM50395272(CHEMBL1231206)
Affinity DataIC50: 2nMAssay Description:Inhibition of human MK2More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetMAP kinase-activated protein kinase 2(Human)
Hefei University of Technology

Curated by ChEMBL
LigandPNGBDBM50395272(CHEMBL1231206)
Affinity DataKi:  3nMAssay Description:Binding affinity to recombinant N-terminal truncated MK2 (45 to 371 residues) (unknown origin) expressed in Escherichia coli assessed as inhibition c...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetMAP kinase-activated protein kinase 5(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50395272(CHEMBL1231206)
Affinity DataIC50: 5nMAssay Description:Inhibition of recombinant PRAK (unknown origin) expressed in Escherichia coli using KKKALSRQLSVAA as substrate incubated for 1 hr followed by substra...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetMAP kinase-activated protein kinase 2(Human)
Hefei University of Technology

Curated by ChEMBL
LigandPNGBDBM50395272(CHEMBL1231206)
Affinity DataIC50: 5nMAssay Description:Binding affinity to recombinant MAPKAP-K2 using KKKALSRQLSVAA as substrate after 4 mins by surface plasmon resonance spectroscopic analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetMAP kinase-activated protein kinase 2(Human)
Hefei University of Technology

Curated by ChEMBL
LigandPNGBDBM50395272(CHEMBL1231206)
Affinity DataKi:  5nMAssay Description:Inhibition of recombinant MK2 (45 to 400 residues) (unknown origin) using fluorescein isothiocyanate-KKKALSRQLSVAA as substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/7/2018
Entry Details Article
PubMed
TargetMAP kinase-activated protein kinase 2(Human)
Hefei University of Technology

Curated by ChEMBL
LigandPNGBDBM50395272(CHEMBL1231206)
Affinity DataIC50: 5.20nMAssay Description:Inhibition of recombinant N-terminal truncated MK2 (45 to 371 residues) (unknown origin) expressed in Escherichia coli using KKKALSRQLSVAA as substra...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetMAP kinase-activated protein kinase 2(Human)
Hefei University of Technology

Curated by ChEMBL
LigandPNGBDBM50395272(CHEMBL1231206)
Affinity DataKd:  5.90nMAssay Description:Binding affinity to recombinant N-terminal truncated MK2 (45 to 371 residues) (unknown origin) expressed in Escherichia coli assessed as dissociation...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetMAP kinase-activated protein kinase 3(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50395272(CHEMBL1231206)
Affinity DataIC50: 53nMAssay Description:Inhibition of recombinant MK3 (unknown origin) expressed in Escherichia coli using KKKALSRQLSVAA as substrate incubated for 1 hr followed by substrat...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
LigandPNGBDBM50395272(CHEMBL1231206)
Affinity DataIC50: 60nMAssay Description:Inhibition of ASK1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetSerine/threonine-protein kinase 17A(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50395272(CHEMBL1231206)
Affinity DataIC50: 71nMAssay Description:Inhibition of DRAK1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetTyrosine-protein kinase Mer(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50395272(CHEMBL1231206)
Affinity DataIC50: 76nMAssay Description:Inhibition of Mer (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetSerine/threonine-protein kinase pim-1(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50395272(CHEMBL1231206)
Affinity DataIC50: 88nMAssay Description:Inhibition of Pim1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetSerine/threonine-protein kinase BRSK2(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50395272(CHEMBL1231206)
Affinity DataIC50: 90nMAssay Description:Inhibition of BrSK2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
LigandPNGBDBM50395272(CHEMBL1231206)
Affinity DataIC50: 148nMAssay Description:Inhibition of recombinant MNK2 (unknown origin) using KKKALSRQLSVAA as substrate incubated for 1 hr followed by substrate addition in presence of ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetSerine/threonine-protein kinase BRSK1(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50395272(CHEMBL1231206)
Affinity DataIC50: 187nMAssay Description:Inhibition of BrSK1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetMAP kinase-activated protein kinase 2(Human)
Hefei University of Technology

Curated by ChEMBL
LigandPNGBDBM50395272(CHEMBL1231206)
Affinity DataIC50: 201nMAssay Description:Inhibition of MK2 in human U937 cells assessed as reduction in LPS-stimulated HSP27 phosphorylation at Ser82 preincubated for 1 hr followed by LPS ad...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2017
Entry Details Article
PubMed
LigandPNGBDBM50395272(CHEMBL1231206)
Affinity DataIC50: 354nMAssay Description:Inhibition of CDK1/cycB (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetTyrosine-protein kinase receptor UFO(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50395272(CHEMBL1231206)
Affinity DataIC50: 428nMAssay Description:Inhibition of Axl (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
LigandPNGBDBM50395272(CHEMBL1231206)
Affinity DataIC50: 528nMAssay Description:Inhibition of PhKgamma2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
LigandPNGBDBM50395272(CHEMBL1231206)
Affinity DataIC50: 590nMAssay Description:Inhibition of RIPK2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
LigandPNGBDBM50395272(CHEMBL1231206)
Affinity DataIC50: 902nMAssay Description:Inhibition of CDK5/p35 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
LigandPNGBDBM50395272(CHEMBL1231206)
Affinity DataIC50: 3.00E+3nMAssay Description:Inhibition of recombinant MNK1 (unknown origin) expressed in Escherichia coli using KKKALSRQLSVAA as substrate incubated for 1 hr followed by substra...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetBile salt export pump(Human)
University of Siena

Curated by ChEMBL
LigandPNGBDBM50395272(CHEMBL1231206)
Affinity DataIC50: 7.00E+3nMAssay Description:Inhibition of human BSEP expressed in recombinant baculovirus infected insect Sf9 cell membrane vesicles assessed as [3H]-taurocholate transport prei...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2017
Entry Details Article
PubMed