BDBM50395274 CHEMBL1235213

SMILES CCOc1ccc(Nc2c(C)c(N[C@H]3CCCNC3)nc3ccnn23)cc1

InChI Key InChIKey=WJOUGMPFYANZMI-INIZCTEOSA-N

Data  7 IC50

PDB links: 2 PDB IDs match this monomer.

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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 50395274   

TargetMAP kinase-activated protein kinase 2(Mus musculus)
Teijin Pharma

Curated by ChEMBL
LigandPNGBDBM50395274(CHEMBL1235213)
Affinity DataIC50:  5.00E+3nMAssay Description:Inhibition of MAPKAP-K2 in mouse whole blood assessed as inhibition of LPS-induced TNFalpha production by ELISAMore data for this Ligand-Target Pair
TargetMAP kinase-activated protein kinase 2(Homo sapiens (Human))
Teijin Pharma

Curated by ChEMBL
LigandPNGBDBM50395274(CHEMBL1235213)
Affinity DataIC50:  1.10E+4nMAssay Description:Inhibition of MAPKAP-K2 in human whole blood assessed as inhibition of LPS-induced TNFalpha production by ELISAMore data for this Ligand-Target Pair
TargetMAP kinase-activated protein kinase 2(Homo sapiens (Human))
Teijin Pharma

Curated by ChEMBL
LigandPNGBDBM50395274(CHEMBL1235213)
Affinity DataIC50:  7.20E+3nMAssay Description:Inhibition of human MAPKAP-K2 in THP1 cells assessed as inhibition of LPS-induced TNFalpha production incubated 1 hr prior to LPS challenge measured ...More data for this Ligand-Target Pair
TargetMAP kinase-activated protein kinase 2(Homo sapiens (Human))
Teijin Pharma

Curated by ChEMBL
LigandPNGBDBM50395274(CHEMBL1235213)
Affinity DataIC50:  130nMAssay Description:Inhibition of MAPKAP-K2 using KKLNRTLSVA as substrate and [33P]-gamma-ATP after 30 mins by liquid scintillation counterMore data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase Chk2(Homo sapiens (Human))
Teijin Pharma

Curated by ChEMBL
LigandPNGBDBM50395274(CHEMBL1235213)
Affinity DataIC50:  1.70E+3nMAssay Description:Inhibition of human CHK2 by radiometric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 2(Homo sapiens (Human))
Teijin Pharma

Curated by ChEMBL
LigandPNGBDBM50395274(CHEMBL1235213)
Affinity DataIC50:  2.30E+4nMAssay Description:Inhibition of CDK2 after 60 mins using [33P]-gamma-ATP by liquid scintillation counterMore data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase Chk2(Homo sapiens (Human))
Teijin Pharma

Curated by ChEMBL
LigandPNGBDBM50395274(CHEMBL1235213)
Affinity DataIC50: >3.00E+4nMAssay Description:Inhibition of human CHK2 by cyclex assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed