BDBM50403531 PF-04418948::Pf-04418948

SMILES COc1ccc2cc(ccc2c1)OCC3(CN(C3)C(=O)c4ccc(cc4)F)C(=O)O

InChI Key InChIKey=LWJGMYMNSNVCEM-UHFFFAOYSA-N

Data  5 KI

PDB links: 1 PDB ID matches this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 50403531   

TargetProstaglandin E2 receptor EP2 subtype(Human)
University of Tennessee Health Science Center

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50403531BDBM50403531(PF-04418948 | Pf-04418948)
Affinity DataKi:  7.60nMAssay Description:Binding affinity to human EP2 receptor expressed in CHO cells assessed as inhibition constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetThromboxane A2 receptor(Human)
Pfizer

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50403531BDBM50403531(PF-04418948 | Pf-04418948)
Affinity DataKi: >1.00E+4nMAssay Description:Displacement of [3H]-Iloprost from human TP receptor assessed as inhibition constant incubated for 2 hrs by TopCount NXT counter based analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetProstaglandin F2-alpha receptor(Human)
Pfizer

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50403531BDBM50403531(PF-04418948 | Pf-04418948)
Affinity DataKi: >1.00E+4nMAssay Description:Displacement of [3H]-Iloprost from human FP receptor assessed as inhibition constant incubated for 2 hrs by TopCount NXT counter based analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetProstaglandin E2 receptor EP4 subtype(Human)
University of Tennessee Health Science Center

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50403531BDBM50403531(PF-04418948 | Pf-04418948)
Affinity DataKi: >1.00E+4nMAssay Description:Binding affinity to human EP4 receptor expressed in CHO cells assessed as inhibition constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMed
TargetProstaglandin E2 receptor EP3 subtype(Human)
University of Tennessee Health Science Center

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50403531BDBM50403531(PF-04418948 | Pf-04418948)
Affinity DataKi: >1.00E+4nMAssay Description:Binding affinity to EP3 receptor (unknown origin) assessed as inhibition constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMed
TargetProstaglandin E2 receptor EP1 subtype(Human)
University of Tennessee Health Science Center

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50403531BDBM50403531(PF-04418948 | Pf-04418948)
Affinity DataKi: >1.00E+4nMAssay Description:Binding affinity to EP1 receptor (unknown origin) assessed as inhibition constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMed
TargetProstaglandin D2 receptor(Human)
University of Tennessee Health Science Center

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50403531BDBM50403531(PF-04418948 | Pf-04418948)
Affinity DataKi: >1.00E+4nMAssay Description:Binding affinity to human DP1 receptor expressed in CHO cells assessed as inhibition constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMed
TargetProstacyclin receptor(Human)
Pfizer

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50403531BDBM50403531(PF-04418948 | Pf-04418948)
Affinity DataKi: >1.00E+4nMAssay Description:Displacement of [3H]-Iloprost from human IP receptor assessed as inhibition constant incubated for 2 hrs by TopCount NXT counter based analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed