BDBM50425008 CHEMBL2312185

SMILES CNc1nc(C)c(s1)-c1nc(Nc2cccc(c2)N2CCCNCC2)ncc1C#N

InChI Key InChIKey=BKOYUSKBPMSUBK-UHFFFAOYSA-N

Data  2 KI  13 IC50

PDB links: 2 PDB IDs match this monomer.

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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 15 hits for monomerid = 50425008   

TargetCyclin-T1/Cyclin-dependent kinase 9(Homo sapiens (Human))
University Of Oxford

Curated by ChEMBL
LigandPNGBDBM50425008(CHEMBL2312185)
Affinity DataKi:  7nMAssay Description:Inhibition of CDK9/Cyclin T (1 to 330 amino acid residues) (unknown origin) by differential scanning fluorimetry assayMore data for this Ligand-Target Pair
TargetCyclin-A1/Cyclin-A2/Cyclin-dependent kinase 2(Homo sapiens (Human))
University Of Oxford

Curated by ChEMBL
LigandPNGBDBM50425008(CHEMBL2312185)
Affinity DataKi:  568nMAssay Description:Inhibition of CDK2/Cyclin A (174 to 432 amino acid residues) (unknown origin) by differential scanning fluorimetry assayMore data for this Ligand-Target Pair
TargetProtein kinase C alpha type(Homo sapiens (Human))
University Of Nottingham

Curated by ChEMBL
LigandPNGBDBM50425008(CHEMBL2312185)
Affinity DataIC50: >5.00E+3nMAssay Description:Inhibition of PKCalpha (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-A1/Cyclin-A2/Cyclin-dependent kinase 2(Homo sapiens (Human))
University Of Oxford

Curated by ChEMBL
LigandPNGBDBM50425008(CHEMBL2312185)
Affinity DataIC50:  1.13E+3nMAssay Description:Inhibition of human recombinant His6 tagged CDK2/Cyclin A expressed in Sf21 insect cells after 40 mins by scintillation counting analysisMore data for this Ligand-Target Pair
TargetCyclin-dependent kinase 6/G1/S-specific cyclin-D3(Homo sapiens (Human))
University Of Nottingham

Curated by ChEMBL
LigandPNGBDBM50425008(CHEMBL2312185)
Affinity DataIC50: >5.00E+3nMAssay Description:Inhibition of human recombinant His6 tagged CDK6/Cyclin D3 expressed in Sf21 insect cells after 40 mins by scintillation counting analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCalcium/calmodulin-dependent protein kinase type 1(Homo sapiens (Human))
University Of Nottingham

Curated by ChEMBL
LigandPNGBDBM50425008(CHEMBL2312185)
Affinity DataIC50: >5.00E+3nMAssay Description:Inhibition of CAMK1 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBreakpoint cluster region protein/Tyrosine-protein kinase ABL1(Homo sapiens (Human))
University Of Nottingham

Curated by ChEMBL
LigandPNGBDBM50425008(CHEMBL2312185)
Affinity DataIC50: >5.00E+3nMAssay Description:Inhibition of BCR/ABL (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProto-oncogene tyrosine-protein kinase Src(Homo sapiens (Human))
University Of Nottingham

Curated by ChEMBL
LigandPNGBDBM50425008(CHEMBL2312185)
Affinity DataIC50: >5.00E+3nMAssay Description:Inhibition of cSRC (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRAC-alpha serine/threonine-protein kinase(Homo sapiens (Human))
University Of Nottingham

Curated by ChEMBL
LigandPNGBDBM50425008(CHEMBL2312185)
Affinity DataIC50: >5.00E+3nMAssay Description:Inhibition of PKBalpha (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMAP kinase-activated protein kinase 2(Homo sapiens (Human))
University Of Nottingham

Curated by ChEMBL
LigandPNGBDBM50425008(CHEMBL2312185)
Affinity DataIC50: >5.00E+3nMAssay Description:Inhibition of MAPK2 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Lck(Homo sapiens (Human))
University Of Nottingham

Curated by ChEMBL
LigandPNGBDBM50425008(CHEMBL2312185)
Affinity DataIC50: >5.00E+3nMAssay Description:Inhibition of LCK (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInhibitor of nuclear factor kappa-B kinase subunit beta(Homo sapiens (Human))
University Of Nottingham

Curated by ChEMBL
LigandPNGBDBM50425008(CHEMBL2312185)
Affinity DataIC50: >5.00E+3nMAssay Description:Inhibition of IKKbeta (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-H/Cyclin-dependent kinase 7(Homo sapiens (Human))
University Of Nottingham

Curated by ChEMBL
LigandPNGBDBM50425008(CHEMBL2312185)
Affinity DataIC50:  92nMAssay Description:Inhibition of human recombinant His6 tagged CDK7/CyclinH/MAT1 expressed in Sf21 insect cells after 40 mins by scintillation counting analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-T1/Cyclin-dependent kinase 9(Homo sapiens (Human))
University Of Oxford

Curated by ChEMBL
LigandPNGBDBM50425008(CHEMBL2312185)
Affinity DataIC50:  14nMAssay Description:Inhibition of human recombinant His6 tagged CDK9/CyclinT1 expressed in Sf21 insect cells after 40 mins by scintillation counting analysisMore data for this Ligand-Target Pair
TargetCyclin-dependent kinase/G2/mitotic-specific cyclin- 1(Homo sapiens (Human))
University Of Nottingham

Curated by ChEMBL
LigandPNGBDBM50425008(CHEMBL2312185)
Affinity DataIC50:  188nMAssay Description:Inhibition of human recombinant His6 tagged CDK1/Cyclin B expressed in Sf21 insect cells after 40 mins by scintillation counting analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed