BDBM50427457 CHEMBL2326952::US10308662, Compound 25::US9505780, 25

SMILES CCOC(=O)c1ccc(cc1)-c1csc2c1oc(cc2=O)N1CCOCC1

InChI Key InChIKey=VRBZWFAUTHKRBB-UHFFFAOYSA-N

Data  16 IC50

PDB links: 1 PDB ID matches this monomer.

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 16 hits for monomerid = 50427457   

TargetBromodomain-containing protein 4 [75-147](Homo sapiens (Human))
Signal Rx Pharmaceuticals

US Patent
LigandPNGBDBM50427457(CHEMBL2326952 | US10308662, Compound 25 | US950578...)
Affinity DataIC50:  277nMAssay Description:Several TP Scaffold compounds were tested for inhibition activity against isoforms of PI3K (alpha, beta, gamma, and delta isoforms) and the bromodoma...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform(Homo sapiens (Human))
Signal Rx Pharmaceuticals

US Patent
LigandPNGBDBM50427457(CHEMBL2326952 | US10308662, Compound 25 | US950578...)
Affinity DataIC50:  1.17E+3nMAssay Description:Inhibitory activity can be determined routinely using known methods and also from commercial vendors offering this service for kinases and bromodomai...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform(Homo sapiens (Human))
Signal Rx Pharmaceuticals

US Patent
LigandPNGBDBM50427457(CHEMBL2326952 | US10308662, Compound 25 | US950578...)
Affinity DataIC50:  714nMAssay Description:Several TP Scaffold compounds were tested for inhibition activity against isoforms of PI3K (alpha, beta, gamma, and delta isoforms) and the bromodoma...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform(Homo sapiens (Human))
Signal Rx Pharmaceuticals

US Patent
LigandPNGBDBM50427457(CHEMBL2326952 | US10308662, Compound 25 | US950578...)
Affinity DataIC50:  1.75E+3nMAssay Description:Several TP Scaffold compounds were tested for inhibition activity against isoforms of PI3K (alpha, beta, gamma, and delta isoforms) and the bromodoma...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform(Homo sapiens (Human))
Signal Rx Pharmaceuticals

US Patent
LigandPNGBDBM50427457(CHEMBL2326952 | US10308662, Compound 25 | US950578...)
Affinity DataIC50:  27nMAssay Description:Several TP Scaffold compounds were tested for inhibition activity against isoforms of PI3K (alpha, beta, gamma, and delta isoforms) and the bromodoma...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform(Homo sapiens (Human))
Signal Rx Pharmaceuticals

US Patent
LigandPNGBDBM50427457(CHEMBL2326952 | US10308662, Compound 25 | US950578...)
Affinity DataIC50:  1.17E+3nMAssay Description:Several TP Scaffold compounds were tested for inhibition activity against isoforms of PI3K (alpha, beta, gamma, and delta isoforms) and the bromodoma...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform(Homo sapiens (Human))
Signal Rx Pharmaceuticals

US Patent
LigandPNGBDBM50427457(CHEMBL2326952 | US10308662, Compound 25 | US950578...)
Affinity DataIC50:  1.17E+3nMAssay Description:Inhibition of PI3K p110gamma (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform(Homo sapiens (Human))
Signal Rx Pharmaceuticals

US Patent
LigandPNGBDBM50427457(CHEMBL2326952 | US10308662, Compound 25 | US950578...)
Affinity DataIC50:  714nMAssay Description:Inhibition of PI3K p110alpha (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform(Homo sapiens (Human))
Signal Rx Pharmaceuticals

US Patent
LigandPNGBDBM50427457(CHEMBL2326952 | US10308662, Compound 25 | US950578...)
Affinity DataIC50:  27nMAssay Description:Inhibition of PI3K p110delta (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform(Homo sapiens (Human))
Signal Rx Pharmaceuticals

US Patent
LigandPNGBDBM50427457(CHEMBL2326952 | US10308662, Compound 25 | US950578...)
Affinity DataIC50:  1.75E+3nMAssay Description:Inhibition of PI3K p110beta (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBromodomain-containing protein 4 [44-167](Homo sapiens (Human))
Signal Rx Pharmaceuticals

US Patent
LigandPNGBDBM50427457(CHEMBL2326952 | US10308662, Compound 25 | US950578...)
Affinity DataIC50:  277nMAssay Description:Inhibitory activity can be determined routinely using known methods and also from commercial vendors offering this service for kinases and bromodomai...More data for this Ligand-Target Pair
TargetBromodomain-containing protein 4 [349-460](Homo sapiens (Human))
Signal Rx Pharmaceuticals

US Patent
LigandPNGBDBM50427457(CHEMBL2326952 | US10308662, Compound 25 | US950578...)
Affinity DataIC50:  628nMAssay Description:Inhibitory activity can be determined routinely using known methods and also from commercial vendors offering this service for kinases and bromodomai...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetPhosphatidylinositol 3-kinase regulatory subunit alpha(Homo sapiens (Human))
Signal Rx Pharmaceuticals

US Patent
LigandPNGBDBM50427457(CHEMBL2326952 | US10308662, Compound 25 | US950578...)
Affinity DataIC50:  714nMAssay Description:Inhibitory activity can be determined routinely using known methods and also from commercial vendors offering this service for kinases and bromodomai...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetPhosphatidylinositol 3-kinase regulatory subunit beta(Homo sapiens (Human))
Signal Rx Pharmaceuticals

US Patent
LigandPNGBDBM50427457(CHEMBL2326952 | US10308662, Compound 25 | US950578...)
Affinity DataIC50:  1.75E+3nMAssay Description:Inhibitory activity can be determined routinely using known methods and also from commercial vendors offering this service for kinases and bromodomai...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform(Homo sapiens (Human))
Signal Rx Pharmaceuticals

US Patent
LigandPNGBDBM50427457(CHEMBL2326952 | US10308662, Compound 25 | US950578...)
Affinity DataIC50:  27nMAssay Description:Inhibitory activity can be determined routinely using known methods and also from commercial vendors offering this service for kinases and bromodomai...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetBromodomain-containing protein 4 [368-440](Homo sapiens (Human))
Signal Rx Pharmaceuticals

US Patent
LigandPNGBDBM50427457(CHEMBL2326952 | US10308662, Compound 25 | US950578...)
Affinity DataIC50:  628nMAssay Description:Several TP Scaffold compounds were tested for inhibition activity against isoforms of PI3K (alpha, beta, gamma, and delta isoforms) and the bromodoma...More data for this Ligand-Target Pair
In DepthDetails US Patent