BDBM50430021 CHEMBL2335864

SMILES COCCNC(=O)c1ccc(Nc2ncc3cc(ccc3n2)-c2ccncc2)cc1

InChI Key InChIKey=NXVFABZXYFFUBF-UHFFFAOYSA-N

Data  2 IC50

PDB links: 1 PDB ID matches this monomer.

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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50430021   

TargetSerine/threonine-protein kinase B-raf(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50430021(CHEMBL2335864)
Affinity DataIC50: >3.00E+4nMAssay Description:Inhibition of human recombinant N-terminus His-tagged BRAF expressed in Sf9 cells coexpressing CDC37 using biotinylated MEK as substrate and MgCl2 in...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRAF proto-oncogene serine/threonine-protein kinase(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50430021(CHEMBL2335864)
Affinity DataIC50:  5.84E+3nMAssay Description:Inhibition of wild type CRAF (unknown origin) using biotinylated MEK as substrate and MgCl2 incubated for 20 mins prior to MgCl2 addition measured af...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed