BDBM50433629 CHEMBL2380845

SMILES O=C(Nc1ccc(Nc2ccnc3[nH]c(=O)c4ccccc4c23)cc1)c1ccccc1

InChI Key InChIKey=XLSPYLMTRXPYKY-UHFFFAOYSA-N

Data  10 IC50

PDB links: 1 PDB ID matches this monomer.

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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 10 hits for monomerid = 50433629   

TargetHigh affinity nerve growth factor receptor(Homo sapiens (Human))
Emd-Serono Research Institute

Curated by ChEMBL
LigandPNGBDBM50433629(CHEMBL2380845)
Affinity DataIC50:  819nMAssay Description:Inhibition of TrkA (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase WNK3(Homo sapiens (Human))
Emd-Serono Research Institute

Curated by ChEMBL
LigandPNGBDBM50433629(CHEMBL2380845)
Affinity DataIC50:  401nMAssay Description:Inhibition of WNK3 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase SIK1(Homo sapiens (Human))
Emd-Serono Research Institute

Curated by ChEMBL
LigandPNGBDBM50433629(CHEMBL2380845)
Affinity DataIC50:  211nMAssay Description:Inhibition of SIK (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetActivated CDC42 kinase 1(Homo sapiens (Human))
Emd-Serono Research Institute

Curated by ChEMBL
LigandPNGBDBM50433629(CHEMBL2380845)
Affinity DataIC50:  149nMAssay Description:Inhibition of ACK1 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAurora kinase B(Homo sapiens (Human))
Emd-Serono Research Institute

Curated by ChEMBL
LigandPNGBDBM50433629(CHEMBL2380845)
Affinity DataIC50:  1nMAssay Description:Inhibition of aurora-B (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLIM domain kinase 1(Homo sapiens (Human))
Emd-Serono Research Institute

Curated by ChEMBL
LigandPNGBDBM50433629(CHEMBL2380845)
Affinity DataIC50:  36nMAssay Description:Inhibition of LIMK1 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProto-oncogene tyrosine-protein kinase receptor Ret(Homo sapiens (Human))
Emd-Serono Research Institute

Curated by ChEMBL
LigandPNGBDBM50433629(CHEMBL2380845)
Affinity DataIC50:  15nMAssay Description:Inhibition of Ret (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAurora kinase B(Homo sapiens (Human))
Emd-Serono Research Institute

Curated by ChEMBL
LigandPNGBDBM50433629(CHEMBL2380845)
Affinity DataIC50:  208nMAssay Description:Inhibition of aurora-B in human MIAPaCa2 cells assessed as reduction of phosphorylation of histone H3More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAurora kinase A(Homo sapiens (Human))
Emd-Serono Research Institute

Curated by ChEMBL
LigandPNGBDBM50433629(CHEMBL2380845)
Affinity DataIC50:  4nMAssay Description:Inhibition of aurora-A (unknown origin)More data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase Chk2(Homo sapiens (Human))
Emd-Serono Research Institute

Curated by ChEMBL
LigandPNGBDBM50433629(CHEMBL2380845)
Affinity DataIC50:  41nMAssay Description:Inhibition of CHK2 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed