BDBM50441566 CHEMBL2436977::US10485800, Example 179
SMILES CN1CCN(Cc2ccc(cc2)-c2cnc3[nH]cc(-c4cnc5[nH]ccc5c4)c3c2)CC1
InChI Key InChIKey=GOTKZROZHBWZJH-UHFFFAOYSA-N
Data 8 IC50
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 8 hits for monomerid = 50441566
TargetInhibitor of nuclear factor kappa-B kinase subunit alpha(Homo sapiens (Human))
Califia Bio
Curated by ChEMBL
Califia Bio
Curated by ChEMBL
Affinity DataIC50: 330nMAssay Description:Inhibition of wild type human IKKa by high throughput ATP-[33P] radiolabeled assayMore data for this Ligand-Target Pair
TargetInhibitor of nuclear factor kappa-B kinase subunit beta(Homo sapiens (Human))
Califia Bio
Curated by ChEMBL
Califia Bio
Curated by ChEMBL
Affinity DataIC50: 288nMAssay Description:Inhibition of wild type human IKKb by high throughput ATP-[33P] radiolabeled assayMore data for this Ligand-Target Pair
Affinity DataIC50: 9.5nMAssay Description:Inhibition of wild type human FLT3 by high throughput ATP-[33P] radiolabeled assayMore data for this Ligand-Target Pair
TargetMitogen-activated protein kinase kinase kinase 11(Homo sapiens (Human))
The University of Rochester
US Patent
The University of Rochester
US Patent
Affinity DataIC50: <100nMAssay Description:200 ng (130 nM) MLK3 (Dundee, DU8313) was incubated with 1 μM inactive MKK7b (Dundee, DU703) in the presence of 2 μM cold ATP (Km) and 0.5 ...More data for this Ligand-Target Pair
Affinity DataIC50: 1.29E+3nMAssay Description:Inhibition of wild type human IR by high throughput ATP-[33P] radiolabeled assayMore data for this Ligand-Target Pair
Affinity DataIC50: 730nMAssay Description:Inhibition of FLT3-L-stimulated wild type full length human FLT3 autophosphorylation expressed in MEF preincubated for 90 mins followed by FLT3-L sti...More data for this Ligand-Target Pair
TargetMitogen-activated protein kinase kinase kinase 11(Homo sapiens (Human))
The University of Rochester
US Patent
The University of Rochester
US Patent
Affinity DataIC50: <100nMAssay Description:200 ng (130 nM) MLK3 (Dundee, DU8313) was incubated with 1 μM inactive MKK7b (Dundee, DU703) in the presence of 2 μM cold ATP (Km) and 0.5 ...More data for this Ligand-Target Pair
TargetMitogen-activated protein kinase kinase kinase 11(Homo sapiens (Human))
The University of Rochester
US Patent
The University of Rochester
US Patent
Affinity DataIC50: 21nMAssay Description:Inhibition of MLK3 (unknown origin) after 20 mins by scintillation counting analysis in presence of [33P]-ATPMore data for this Ligand-Target Pair