BDBM50444444 CHEMBL3092375

SMILES CC(O)C(C)(C)Cc1noc(n1)-c1sc(NC(C)=O)nc1C

InChI Key InChIKey=GLQCVWRAOZDVOA-UHFFFAOYSA-N

Data  2 IC50

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50444444   

TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform(Human)
Taisho Pharmaceutical

Curated by ChEMBL

LigandBDBM50444444(CHEMBL3092375)Copy SMILESCopy InChI

Affinity DataIC50: 17nMAssay Description:Inhibition of human PI3Kgamma using PtdIns/PtdSer as substrate after 2 hrs by scintillation counting analysis in presence of gamma[33P]ATPMore data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoCHEMBLPC cidPC sidSimilars

In Depth
Date in BDB:
7/25/2014
Entry Details Article
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TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform(Mouse)
Taisho Pharmaceutical

Curated by ChEMBL

LigandBDBM50444444(CHEMBL3092375)Copy SMILESCopy InChI

Affinity DataIC50: 155nMAssay Description:Inhibition of PI3Kgamma in mouse RAW264.7 cells assessed as C5a-mediated PKB/Akt phosphorylation preincubated for 30 mins followed by C5a stimulation...More data for this Ligand-Target Pair

Target InfoPDB
UniProtKB/SwissProt
GoogleScholar

Ligand InfoCHEMBLPC cidPC sidSimilars

In Depth
Date in BDB:
7/25/2014
Entry Details Article
Copy BDB DOIPubMed
Copy reaction URL