BDBM50449472 CHEBI:75379::CHEMBL1328324::US20250163056, Compound BPN-0025110

SMILES Cc1ccc2c(c1)C(=O)[C@@]3(CCN(C3=N2)c4ccccc4)O

InChI Key InChIKey=LZAXPYOBKSJSEX-UHFFFAOYSA-N

Data  2 KI  14 IC50  1 EC50

PDB links: 3 PDB IDs match this monomer.

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 17 hits for monomerid = 50449472   

TargetMyosin-4(Rabbit)
Ghent University

Curated by ChEMBL
LigandPNGBDBM50449472(CHEMBL1328324 | CHEBI:75379 | US20250163056, Compo...)
Affinity DataIC50: 220nMAssay Description:Inhibition of rabbit skeletal muscle myosin 2More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetMyosin-7(Pig)
Ghent University

Curated by ChEMBL
LigandPNGBDBM50449472(CHEMBL1328324 | CHEBI:75379 | US20250163056, Compo...)
Affinity DataIC50: 1.20E+3nMAssay Description:Inhibition of pig beta cardiac myosin 2 by NADH-coupled spectrophotometric analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetNonmuscle myosin heavy chain(Chicken)
Ghent University

Curated by ChEMBL
LigandPNGBDBM50449472(CHEMBL1328324 | CHEBI:75379 | US20250163056, Compo...)
Affinity DataIC50: 1.80E+3nMAssay Description:Inhibition of chicken non-muscle myosin 2b by NADH-coupled spectrophotometric analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetMyosin-14(Mouse)
Ghent University

Curated by ChEMBL
LigandPNGBDBM50449472(CHEMBL1328324 | CHEBI:75379 | US20250163056, Compo...)
Affinity DataIC50: 3.20E+3nMAssay Description:Inhibition of mouse non-muscle myosin 2cMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetMyosin-9(Human)
University of Florida Research Foundation

US Patent
LigandPNGBDBM50449472(CHEMBL1328324 | CHEBI:75379 | US20250163056, Compo...)
Affinity DataEC50:  3.20E+3nMAssay Description:Cytokinesis is a cell-based assay to assess nonmuscle myosin II function, performed using COS7 cells. The assay is run in a 96 well plate, with 2,000...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/19/2025
Entry Details
Go to US Patent

TargetMyosin-9(Human)
University of Florida Research Foundation

US Patent
LigandPNGBDBM50449472(CHEMBL1328324 | CHEBI:75379 | US20250163056, Compo...)
Affinity DataIC50: 4.00E+3nMAssay Description:Inhibition of human non-muscle myosin 2aMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetMyosin-10(Human)
Ghent University

Curated by ChEMBL
LigandPNGBDBM50449472(CHEMBL1328324 | CHEBI:75379 | US20250163056, Compo...)
Affinity DataIC50: 4.60E+3nMAssay Description:Inhibition of human non-muscle myosin 2bMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetMyosin-2 heavy chain(Social amoeba)
Ghent University

Curated by ChEMBL
LigandPNGBDBM50449472(CHEMBL1328324 | CHEBI:75379 | US20250163056, Compo...)
Affinity DataIC50: 4.90E+3nMAssay Description:Inhibition of RLC-phosphorylated Dictyostelium discoideum myosin 2 ATPase activity by NADH-coupled spectrophotometric analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetMyosin-2(Human)
University of Florida Research Foundation

US Patent
LigandPNGBDBM50449472(CHEMBL1328324 | CHEBI:75379 | US20250163056, Compo...)
Affinity DataKi:  8.00E+3nMAssay Description:The skeletal muscle myosin II actin-activated ATPase assay is performed the same as for cardiac muscle myosin II with the following exceptions: Rabbi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/19/2025
Entry Details
Go to US Patent

TargetMyosin light chain kinase 2, skeletal/cardiac muscle(Human)
University of Florida Research Foundation

US Patent
LigandPNGBDBM50449472(CHEMBL1328324 | CHEBI:75379 | US20250163056, Compo...)
Affinity DataKi:  2.20E+4nMAssay Description:The cardiac muscle myosin II actin-activated ATPase assay is a biochemical assay. Specifically, it is an NADH (nicotinamide adenine dinucleotide)-cou...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/19/2025
Entry Details
Go to US Patent

TargetMyosin-2 heavy chain, non muscle(Amoeba)
Ghent University

Curated by ChEMBL
LigandPNGBDBM50449472(CHEMBL1328324 | CHEBI:75379 | US20250163056, Compo...)
Affinity DataIC50: 8.30E+4nMAssay Description:Inhibition of dephosphorylated Acanthamoeba non muscle myosin 2 by NADH-coupled spectrophotometric analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetUnconventional myosin-XV(Human)
Ghent University

Curated by ChEMBL
LigandPNGBDBM50449472(CHEMBL1328324 | CHEBI:75379 | US20250163056, Compo...)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of human myosin 15 by NADH-coupled spectrophotometric analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetUnconventional myosin-Va(Mouse)
Ghent University

Curated by ChEMBL
LigandPNGBDBM50449472(CHEMBL1328324 | CHEBI:75379 | US20250163056, Compo...)
Affinity DataIC50: 1.50E+5nMAssay Description:Inhibition of mouse myosin 5a by NADH-coupled spectrophotometric analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetMyosin IC heavy chain(Amoeba)
Ghent University

Curated by ChEMBL
LigandPNGBDBM50449472(CHEMBL1328324 | CHEBI:75379 | US20250163056, Compo...)
Affinity DataIC50: 1.50E+5nMAssay Description:Inhibition of dephosphorylated Acanthamoeba muscle myosin 1c by NADH-coupled spectrophotometric analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetUnconventional myosin-Ib(Rat)
Ghent University

Curated by ChEMBL
LigandPNGBDBM50449472(CHEMBL1328324 | CHEBI:75379 | US20250163056, Compo...)
Affinity DataIC50: 1.50E+5nMAssay Description:Inhibition of rat myosin 1b by NADH-coupled spectrophotometric analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetUnconventional myosin-X(Bovine)
Ghent University

Curated by ChEMBL
LigandPNGBDBM50449472(CHEMBL1328324 | CHEBI:75379 | US20250163056, Compo...)
Affinity DataIC50: 1.50E+5nMAssay Description:Inhibition of bovine myosin x by NADH-coupled spectrophotometric analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetMyosin heavy chain, non-muscle(Fruit fly)
Ghent University

Curated by ChEMBL
LigandPNGBDBM50449472(CHEMBL1328324 | CHEBI:75379 | US20250163056, Compo...)
Affinity DataIC50: 2.00E+5nMAssay Description:Inhibition of fruit fly non-muscle myosin 2More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed