BDBM50453816 BGB-283::Bgb 283::Lifirafenib

SMILES [H][C@]12Oc3ccc(Oc4ccnc5NC(=O)CCc45)cc3[C@@]1([H])[C@@H]2c1nc2cc(ccc2[nH]1)C(F)(F)F

InChI Key InChIKey=NGFFVZQXSRKHBM-FKBYEOEOSA-N

Data  1 IC50

PDB links: 1 PDB ID matches this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50453816   

TargetSerine/threonine-protein kinase B-raf(Homo sapiens (Human))
Temple University

Curated by ChEMBL
LigandPNGBDBM50453816(BGB-283 | Bgb 283 | Lifirafenib)
Affinity DataIC50:  23nMAssay Description:Inhibition of BRAF (unknown origin) using MEK1 K97R mutant as substrate preincubated for 60 to 120 mins followed by substrate addition measured after...More data for this Ligand-Target Pair