BDBM50453821 CHEMBL4206831

SMILES CCC(=O)Nc1ccc(cc1)C(=O)Nc1ccc(Nc2ncc3N(C)C(=O)c4cc(C)ccc4N(C)c3n2)cc1

InChI Key InChIKey=KGXBCWANASZZQG-UHFFFAOYSA-N

Data  6 IC50  2 EC50

PDB links: 1 PDB ID matches this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 50453821   

TargetAurora kinase A(Homo sapiens (Human))
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM50453821(CHEMBL4206831)
Affinity DataIC50:  52nMAssay Description:Inhibition of recombinant full length His-tagged human Aurora A expressed in baculovirus expression system by Z'LYTE assayMore data for this Ligand-Target Pair
TargetAurora kinase B(Homo sapiens (Human))
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM50453821(CHEMBL4206831)
Affinity DataIC50:  41nMAssay Description:Inhibition of recombinant full length His-tagged human Aurora B expressed in baculovirus expression system by Z'LYTE assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAurora kinase A(Homo sapiens (Human))
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM50453821(CHEMBL4206831)
Affinity DataEC50:  38nMAssay Description:Inhibition of Aurora A auto-phosphorylation in human HCT116 cells after 4 hrs by Western blot analysisMore data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase PLK4(Homo sapiens (Human))
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM50453821(CHEMBL4206831)
Affinity DataIC50:  82nMAssay Description:Inhibition of GST-tagged human PLK4 (1 to 836 residues) by Lanthascreen binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLeucine-rich repeat serine/threonine-protein kinase 2(Homo sapiens (Human))
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM50453821(CHEMBL4206831)
Affinity DataIC50:  714nMAssay Description:Inhibition of recombinant GST-tagged human LRRK2 (970 to 2527 residues) catalytic domain expressed in baculovirus expression system by ADAPTA assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBromodomain-containing protein 4(Homo sapiens (Human))
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM50453821(CHEMBL4206831)
Affinity DataIC50:  3.40E+4nMAssay Description:Inhibition of BRD4 (unknown origin) by AlphaScreen assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAurora kinase C(Homo sapiens (Human))
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM50453821(CHEMBL4206831)
Affinity DataIC50:  53nMAssay Description:Inhibition of recombinant full length GST-tagged human Aurora C expressed in baculovirus expression system by Z'LYTE assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAurora kinase B(Homo sapiens (Human))
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM50453821(CHEMBL4206831)
Affinity DataEC50:  11nMAssay Description:Inhibition of Aurora B in human HCT116 cells assessed as reduction in histone H3 phosphorylation at S10 residues after 4 hrs by Western blot analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed