BDBM50455347 CHEMBL4217649

SMILES CCN1CCN(CC1)c1ccc(cn1)-c1nn(Cc2cn(Cc3ccccc3)nn2)c2nc(NC)ncc12

InChI Key InChIKey=PAZDHXLZWBCXCX-UHFFFAOYSA-N

Data  12 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 12 hits for monomerid = 50455347   

TargetTyrosine-protein kinase receptor TYRO3(Human)
University of Edinburgh

Curated by ChEMBL
LigandPNGBDBM50455347(CHEMBL4217649)
Affinity DataIC50: 1.90E+3nMAssay Description:Inhibition of wild-type human partial length TYRO3 (S497 to T814 residues) expressed in bacterial expression system using poly [Glu, Try] 4:1 as subs...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetRAC-alpha serine/threonine-protein kinase(Human)
University of Edinburgh

Curated by ChEMBL
LigandPNGBDBM50455347(CHEMBL4217649)
Affinity DataIC50: 1.90E+3nMAssay Description:Inhibition of AKT (unknown origin) using poly [Glu, Try] 4:1 as substrate in presence of [gamma-33P]ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetProto-oncogene tyrosine-protein kinase receptor Ret(Human)
University of Edinburgh

Curated by ChEMBL
LigandPNGBDBM50455347(CHEMBL4217649)
Affinity DataIC50: 6.20E+3nMAssay Description:Inhibition of wild-type human partial length RET (E713 to D1014 residues) expressed in bacterial expression system using poly [Glu, Try] 4:1 as subst...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetHepatocyte growth factor receptor(Human)
University of Edinburgh

Curated by ChEMBL
LigandPNGBDBM50455347(CHEMBL4217649)
Affinity DataIC50: 6.30E+3nMAssay Description:Inhibition of wild-type human partial length MET (D1010 to S1367 residues) expressed in bacterial expression system using poly [Glu, Try] 4:1 as subs...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetVascular endothelial growth factor receptor 2(Human)
University of Edinburgh

Curated by ChEMBL
LigandPNGBDBM50455347(CHEMBL4217649)
Affinity DataIC50: 7.70E+3nMAssay Description:Inhibition of wild-type human partial length VEGFR2 (R787 to P1253 residues) expressed in mammalian expression system using poly [Glu, Try] 4:1 as su...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetProto-oncogene tyrosine-protein kinase Src(Human)
University of Edinburgh

Curated by ChEMBL
LigandPNGBDBM50455347(CHEMBL4217649)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of wild-type human partial length SRC (L240 to L536 residues) expressed in bacterial expression system using poly [Glu, Try] 4:1 as substr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Human)
University of Edinburgh

Curated by ChEMBL
LigandPNGBDBM50455347(CHEMBL4217649)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of wild-type human partial length FLT3 (V592 to Y969 residues) expressed in bacterial expression system using poly [Glu, Try] 4:1 as subst...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase mTOR(Human)
University of Edinburgh

Curated by ChEMBL
LigandPNGBDBM50455347(CHEMBL4217649)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of wild-type human partial length MTOR (L1382 to W2549 residues) expressed in mammalian expression system using poly [Glu, Try] 4:1 as sub...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetMast/stem cell growth factor receptor Kit(Human)
University of Edinburgh

Curated by ChEMBL
LigandPNGBDBM50455347(CHEMBL4217649)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of wild-type human partial length KIT (I571 to D952 residues) expressed in bacterial expression system using poly [Glu, Try] 4:1 as substr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetTyrosine-protein kinase receptor UFO(Human)
University of Edinburgh

Curated by ChEMBL
LigandPNGBDBM50455347(CHEMBL4217649)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of wild-type human partial length AXL (R497 to Y821 residues) expressed in bacterial expression system using poly [Glu, Try] 4:1 as substr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetTyrosine-protein kinase Mer(Human)
University of Edinburgh

Curated by ChEMBL
LigandPNGBDBM50455347(CHEMBL4217649)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of wild-type human partial length MER (R557 to L884 residues) expressed in bacterial expression system using poly [Glu, Try] 4:1 as substr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetAurora kinase A(Human)
University of Edinburgh

Curated by ChEMBL
LigandPNGBDBM50455347(CHEMBL4217649)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human partial length Aurora A (E122 to K401 residues) expressed in mammalian expression system using poly [Glu, Try] 4:1 as substrate i...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed