BDBM50458051 CHEMBL4206061::US10988476, Compound I-23
SMILES CC(C)n1c(C)nc2c(F)cc(cc12)-c1nc(Nc2ccc3CN(CCc3n2)C(=O)CN2CCN(C)CC2)ncc1F
InChI Key InChIKey=KZZDDXBCJROTIP-UHFFFAOYSA-N
Data 8 IC50
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 8 hits for monomerid = 50458051
TargetCyclin-dependent kinase/G2/mitotic-specific cyclin- 1(Homo sapiens (Human))
Shanghai Haihe Pharmaceutical
Curated by ChEMBL
Shanghai Haihe Pharmaceutical
Curated by ChEMBL
Affinity DataIC50: 236nMAssay Description:Inhibition of human CDK1/Cyclin-B using ULight-substrate after 1 hr by LANCE assayMore data for this Ligand-Target Pair
TargetCyclin-dependent kinase 4/G1/S-specific cyclin-E1(Homo sapiens (Human))
Shanghai Haihe Pharmaceutical
Curated by ChEMBL
Shanghai Haihe Pharmaceutical
Curated by ChEMBL
Affinity DataIC50: 1.60nMAssay Description:Inhibition of human CDK4/cyclin D1 using ULight-substrate after 1 hr by LANCE assayMore data for this Ligand-Target Pair
Affinity DataIC50: 2.88nMAssay Description:1. Take 10 mM stock solution of the test compound, in 96-well compound plate, DMSO was used to dilute the compound to an initial concentration of 100...More data for this Ligand-Target Pair
Affinity DataIC50: 8.21nMAssay Description:1. Take 10 mM stock solution of the test compound, in 96-well compound plate, DMSO was used to dilute the compound to an initial concentration of 100...More data for this Ligand-Target Pair
Affinity DataIC50: 14.8nMAssay Description:1. Take 10 mM stock solution of the test compound, in 96-well compound plate, DMSO was used to dilute the compound to an initial concentration of 100...More data for this Ligand-Target Pair
Affinity DataIC50: 44.8nMAssay Description:1. Take 10 mM stock solution of the test compound, in 96-well compound plate, DMSO was used to dilute the compound to an initial concentration of 100...More data for this Ligand-Target Pair
Affinity DataIC50: 801nMAssay Description:1. Take 10 mM stock solution of the test compound, in 96-well compound plate, DMSO was used to dilute the compound to an initial concentration of 100...More data for this Ligand-Target Pair
Affinity DataIC50: 4.17nMAssay Description:1. Take 10 mM stock solution of the test compound, in 96-well compound plate, DMSO was used to dilute the compound to an initial concentration of 100...More data for this Ligand-Target Pair