BDBM50459942 CHEMBL4227864::US10730870, Example 85::US11512083, Example 85

SMILES C[C@H](NC(C)=O)C(=O)N1C[C@H](O)C[C@H]1C(=O)NCc1ccc(cc1)-c1scnc1C

InChI Key InChIKey=JKHAXURJIZDRKK-VHSSKADRSA-N

Data  4 IC50  3 Kd

PDB links: 1 PDB ID matches this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 50459942   

TargetElongin-C(Homo sapiens (Human))
University Of Dundee

Curated by ChEMBL
LigandPNGBDBM50459942(CHEMBL4227864 | US10730870, Example 85 | US1151208...)
Affinity DataKd:  440nMAssay Description:Binding affinity to VBC complex (unknown origin) by ITC assayMore data for this Ligand-Target Pair
TargetElongin-C(Homo sapiens (Human))
University Of Dundee

Curated by ChEMBL
LigandPNGBDBM50459942(CHEMBL4227864 | US10730870, Example 85 | US1151208...)
Affinity DataKd:  690nMAssay Description:Binding affinity to VBC complex (unknown origin) assessed as reduction of FAM-labelled HIF1alpha peptide binding by fluorescence polarization assayMore data for this Ligand-Target Pair
TargetElongin-C(Homo sapiens (Human))
University Of Dundee

Curated by ChEMBL
LigandPNGBDBM50459942(CHEMBL4227864 | US10730870, Example 85 | US1151208...)
Affinity DataKd:  760nMAssay Description:Displacement of FAM-labeled HIF-1alpha peptide from VBC (unknown origin) by fluorescence polarization assayMore data for this Ligand-Target Pair
TargetVHL complex(Homo sapiens (Human))
Arvinas Operations

US Patent
LigandPNGBDBM50459942(CHEMBL4227864 | US10730870, Example 85 | US1151208...)
Affinity DataIC50:  2.12E+4nMAssay Description:Ability of VHL ligands to compete for the HIF 1 a binding site on VCB was determined through a fluorescence polarization competition assay as describ...More data for this Ligand-Target Pair
Targetvon Hippel-Lindau disease tumor suppressor(Homo sapiens (Human))
Arvinas Operations

US Patent
LigandPNGBDBM50459942(CHEMBL4227864 | US10730870, Example 85 | US1151208...)
Affinity DataIC50:  2.12E+4nMAssay Description:Ability of VHL ligands to compete for the HIF 1 a binding site on VCB was determined through a fluorescence polarization competition assay as describ...More data for this Ligand-Target Pair
TargetVHL complex(Homo sapiens (Human))
Arvinas Operations

US Patent
LigandPNGBDBM50459942(CHEMBL4227864 | US10730870, Example 85 | US1151208...)
Affinity DataIC50:  2.89E+4nMAssay Description:Ability of VHL ligands to compete for the HIF 1 a binding site on VCB was determined through a fluorescence polarization competition assay as describ...More data for this Ligand-Target Pair
Targetvon Hippel-Lindau disease tumor suppressor(Homo sapiens (Human))
Arvinas Operations

US Patent
LigandPNGBDBM50459942(CHEMBL4227864 | US10730870, Example 85 | US1151208...)
Affinity DataIC50:  2.89E+4nMAssay Description:Ability of VHL ligands to compete for the HIF 1 a binding site on VCB was determined through a fluorescence polarization competition assay as describ...More data for this Ligand-Target Pair