BDBM504660 US11066396, Example 91::tert-butyl (3- fluorophenyl)((5- (5-(trifluoromethyl)- 1,2,4-oxadiazol-3- yl)pyridin-2- yl)methyl) carbamate

SMILES CC(C)(C)OC(=O)N(Cc1ccc(cn1)-c1noc(n1)C(F)(F)F)c1cccc(F)c1

InChI Key InChIKey=RBELYUYLMZWVHU-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 504660   

TargetHistone deacetylase 6(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM504660(tert-butyl (3- fluorophenyl)((5- (5-(trifluorometh...)
Affinity DataIC50: 54nMAssay Description:HDAC1 and 6 reagents: FLAG-tagged HDACs 1 and 6 were prepared in-house by protein expression in HEK293F cells followed by anti-FLAG affinity purifica...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2021
Entry Details
US Patent

TargetHistone deacetylase 1(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM504660(tert-butyl (3- fluorophenyl)((5- (5-(trifluorometh...)
Affinity DataIC50: 1.30E+3nMAssay Description:HDAC1 and 6 reagents: FLAG-tagged HDACs 1 and 6 were prepared in-house by protein expression in HEK293F cells followed by anti-FLAG affinity purifica...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2021
Entry Details
US Patent

TargetHistone deacetylase 8(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM504660(tert-butyl (3- fluorophenyl)((5- (5-(trifluorometh...)
Affinity DataIC50: 1.90E+4nMAssay Description:HDAC8 reagents: HDAC8 was purchased from Enzo Life Sciences [catalog #BML-SE145]. Assays were performed with buffer containing 20 mM HEPES, pH 8.0 [B...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2021
Entry Details
US Patent