BDBM504762 Methyl(2-(5-(5-(trifluoromethyl)-1,2,4-oxadiazol-3-l)pyridin-2-yl)-1-(3-trifluoromethyl)phenyl)ethyl)carbamate::US11066396, Example 180

SMILES COC(=O)NC(Cc1ccc(cn1)-c1noc(n1)C(F)(F)F)c1cccc(c1)C(F)(F)F

InChI Key InChIKey=PCLXEVPBERFERU-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 504762   

TargetHistone deacetylase 6(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM504762(Methyl(2-(5-(5-(trifluoromethyl)-1,2,4-oxadiazol-3...)
Affinity DataIC50: 48nMAssay Description:HDAC1 and 6 reagents: FLAG-tagged HDACs 1 and 6 were prepared in-house by protein expression in HEK293F cells followed by anti-FLAG affinity purifica...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2021
Entry Details
US Patent

TargetHistone deacetylase 1(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM504762(Methyl(2-(5-(5-(trifluoromethyl)-1,2,4-oxadiazol-3...)
Affinity DataIC50: 650nMAssay Description:HDAC1 and 6 reagents: FLAG-tagged HDACs 1 and 6 were prepared in-house by protein expression in HEK293F cells followed by anti-FLAG affinity purifica...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2021
Entry Details
US Patent

TargetHistone deacetylase 5(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM504762(Methyl(2-(5-(5-(trifluoromethyl)-1,2,4-oxadiazol-3...)
Affinity DataIC50: 650nMAssay Description:HDAC5 reagents: N-terminal GST tagged HDAC5 was purchased from BPS Bioscience [catalog #50045]. Assays were performed with buffer containing 20 mM HE...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2021
Entry Details
US Patent