BDBM504765 Methyl(4-(5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl)benzyl)(3-(trifluoromethyl)phenyl)carbamate::US11066396, Example 181

SMILES COC(=O)N(Cc1ccc(cc1)-c1noc(n1)C(F)(F)F)c1cccc(c1)C(F)(F)F

InChI Key InChIKey=QELGYXJGYBLQLW-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 504765   

TargetHistone deacetylase 6(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM504765(Methyl(4-(5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl...)
Affinity DataIC50:  550nMAssay Description:HDAC1 and 6 reagents: FLAG-tagged HDACs 1 and 6 were prepared in-house by protein expression in HEK293F cells followed by anti-FLAG affinity purifica...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetHistone deacetylase 5(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM504765(Methyl(4-(5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl...)
Affinity DataIC50:  1.80E+3nMAssay Description:HDAC5 reagents: N-terminal GST tagged HDAC5 was purchased from BPS Bioscience [catalog #50045]. Assays were performed with buffer containing 20 mM HE...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetHistone deacetylase 1(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM504765(Methyl(4-(5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl...)
Affinity DataIC50:  3.30E+3nMAssay Description:HDAC1 and 6 reagents: FLAG-tagged HDACs 1 and 6 were prepared in-house by protein expression in HEK293F cells followed by anti-FLAG affinity purifica...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent