BDBM50478215 CHEBI:474180::Cancidas::Caspofungin::Caspofungin Acetate::L-743,872::L-743872::MK-991

SMILES [H][C@@]12C[C@@H](O)CN1C(=O)[C@@]([H])(NC(=O)[C@H](C[C@@H](O)[C@@H](NCCN)NC(=O)[C@]1([H])[C@@H](O)CCN1C(=O)[C@@]([H])(NC(=O)[C@@]([H])(NC2=O)[C@H](O)[C@@H](O)c1ccc(O)cc1)[C@H](O)CCN)NC(=O)CCCCCCCCC(C)CC(C)CC)[C@@H](C)O

InChI Key InChIKey=JYIKNQVWKBUSNH-OGZDCFRISA-N

Data  38 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 38 hits for monomerid = 50478215   

Target1,3-beta-glucan synthase(Yeast)
Rutgers University

Curated by ChEMBL
LigandPNGBDBM50478215(CHEBI:474180 | Cancidas | Caspofungin | Caspofungi...)
Affinity DataIC50: 6.80nMAssay Description:Inhibition of FKS1 from Candida krusei 98 isolateMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
Target1,3-beta-glucan synthase(Yeast)
Public Health Research Institute

Curated by ChEMBL
LigandPNGBDBM50478215(CHEBI:474180 | Cancidas | Caspofungin | Caspofungi...)
Affinity DataIC50: 81nMAssay Description:Inhibition of glucan synthase in Candida albicans SC5314 in presence of 50% human serumMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
Target1,3-beta-glucan synthase(Yeast)
Public Health Research Institute

Curated by ChEMBL
LigandPNGBDBM50478215(CHEBI:474180 | Cancidas | Caspofungin | Caspofungi...)
Affinity DataIC50: 1.30nMAssay Description:Inhibition of glucan synthase in Candida albicans 36082 assessed as incorporation of [3H]uridine diphosphoglucose in presence of 10% serumMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
Target1,3-beta-glucan synthase(Yeast)
Public Health Research Institute

Curated by ChEMBL
LigandPNGBDBM50478215(CHEBI:474180 | Cancidas | Caspofungin | Caspofungi...)
Affinity DataIC50: 0.330nMAssay Description:Inhibition of glucan synthase in Candida albicans 36082 assessed as incorporation of [3H]uridine diphosphoglucoseMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
Target1,3-beta-glucan synthase(Yeast)
Public Health Research Institute

Curated by ChEMBL
LigandPNGBDBM50478215(CHEBI:474180 | Cancidas | Caspofungin | Caspofungi...)
Affinity DataIC50: 1.90nMAssay Description:Inhibition of glucan synthase in Candida albicans 36082 assessed as incorporation of [3H]uridine diphosphoglucose in presence of 20% serumMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
Target1,3-beta-glucan synthase(Yeast)
Public Health Research Institute

Curated by ChEMBL
LigandPNGBDBM50478215(CHEBI:474180 | Cancidas | Caspofungin | Caspofungi...)
Affinity DataIC50: 0.900nMAssay Description:Inhibition of glucan synthase in Candida albicans ATCC 36082More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
Target1,3-beta-glucan synthase(Yeast)
Public Health Research Institute

Curated by ChEMBL
LigandPNGBDBM50478215(CHEBI:474180 | Cancidas | Caspofungin | Caspofungi...)
Affinity DataIC50: 13.4nMAssay Description:Inhibition of glucan synthase in Candida albicans SC5314More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
Target1,3-beta-glucan synthase(Yeast)
Public Health Research Institute

Curated by ChEMBL
LigandPNGBDBM50478215(CHEBI:474180 | Cancidas | Caspofungin | Caspofungi...)
Affinity DataIC50: 6.20nMAssay Description:Inhibition of glucan synthase in Candida albicans 36082 assessed as incorporation of [3H]uridine diphosphoglucose in presence of 50% serumMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
Target1,3-beta-glucan synthase(Yeast)
Public Health Research Institute

Curated by ChEMBL
LigandPNGBDBM50478215(CHEBI:474180 | Cancidas | Caspofungin | Caspofungi...)
Affinity DataIC50: 2.10nMAssay Description:Inhibition of glucan synthase in Candida albicans ATCC 90028 in presence of 20% human serumMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
Target1,3-beta-glucan synthase(Yeast)
Public Health Research Institute

Curated by ChEMBL
LigandPNGBDBM50478215(CHEBI:474180 | Cancidas | Caspofungin | Caspofungi...)
Affinity DataIC50: 27nMAssay Description:Inhibition of glucan synthase in Candida albicans SC5314 in presence of 10% human serumMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
Target1,3-beta-glucan synthase(Yeast)
Public Health Research Institute

Curated by ChEMBL
LigandPNGBDBM50478215(CHEBI:474180 | Cancidas | Caspofungin | Caspofungi...)
Affinity DataIC50: 37nMAssay Description:Inhibition of glucan synthase in Candida albicans SC5314 in presence of 20% human serumMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
Target1,3-beta-glucan synthase(Yeast)
Rutgers University

Curated by ChEMBL
LigandPNGBDBM50478215(CHEBI:474180 | Cancidas | Caspofungin | Caspofungi...)
Affinity DataIC50: 3.94E+3nMAssay Description:Inhibition of FKS1 T2080K mutant from Candida krusei 100 isolateMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
Target1,3-beta-glucan synthase(Yeast)
University of Medicine and Dentistry of New Jersey

Curated by ChEMBL
LigandPNGBDBM50478215(CHEBI:474180 | Cancidas | Caspofungin | Caspofungi...)
Affinity DataIC50: 370nMAssay Description:Inhibition of Candida tropicalis T3 blood stream isolate glucan synthase subunit FKS1p with FLTLS/PLRDP mutant at biphasic kineticsMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
Target1,3-beta-glucan synthase(Yeast)
University of Medicine and Dentistry of New Jersey

Curated by ChEMBL
LigandPNGBDBM50478215(CHEBI:474180 | Cancidas | Caspofungin | Caspofungi...)
Affinity DataIC50: 0.296nMAssay Description:Inhibition of Candida tropicalis T19 blood stream isolate glucan synthase subunit FKS1p with FLTLS/PLRDP mutant at monophasic kineticsMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
Target1,3-beta-glucan synthase(Yeast)
University of Medicine and Dentistry of New Jersey

Curated by ChEMBL
LigandPNGBDBM50478215(CHEBI:474180 | Cancidas | Caspofungin | Caspofungi...)
Affinity DataIC50: 264nMAssay Description:Inhibition of Candida tropicalis T19 blood stream isolate glucan synthase subunit FKS1p with FLTLS/PLRDP mutant at biphasic kineticsMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
Target1,3-beta-D-glucan synthase catalytic subunit(Yeast)
University of Medicine and Dentistry of New Jersey

Curated by ChEMBL
LigandPNGBDBM50478215(CHEBI:474180 | Cancidas | Caspofungin | Caspofungi...)
Affinity DataIC50: 0.5nMAssay Description:Inhibition of Candida albicans ATCC 90028 glucan synthase at monophasic kineticsMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
Target1,3-beta-glucan synthase(Yeast)
University of Medicine and Dentistry of New Jersey

Curated by ChEMBL
LigandPNGBDBM50478215(CHEBI:474180 | Cancidas | Caspofungin | Caspofungi...)
Affinity DataIC50: 0.306nMAssay Description:Inhibition of Candida tropicalis T3 blood stream isolate glucan synthase subunit FKS1p with FLTLS/PLRDP mutant at monophasic kineticsMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
Target1,3-beta-glucan synthase(Yeast)
University of Medicine and Dentistry of New Jersey

Curated by ChEMBL
LigandPNGBDBM50478215(CHEBI:474180 | Cancidas | Caspofungin | Caspofungi...)
Affinity DataIC50: 77nMAssay Description:Inhibition of Candida tropicalis T26 blood stream isolate glucan synthase subunit FKS1p with LLTLSLRDP mutant at monophasic kineticsMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetBroad substrate specificity ATP-binding cassette transporter ABCG2(Human)
Federal University of Parana

Curated by ChEMBL
LigandPNGBDBM50478215(CHEBI:474180 | Cancidas | Caspofungin | Caspofungi...)
Affinity DataIC50: 6.00E+3nMAssay Description:Inhibition of ABCG2 (unknown origin) expressed in human HEK293 cells membrane vesicles assessed inhibition of BCRP- mediated transport of 3[H]-E1S fo...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
PubMed
Target1,3-beta-glucan synthase(Yeast)
University of Medicine and Dentistry of New Jersey

Curated by ChEMBL
LigandPNGBDBM50478215(CHEBI:474180 | Cancidas | Caspofungin | Caspofungi...)
Affinity DataIC50: 4.99E+3nMAssay Description:Inhibition of Candida glabrata isolate 5847 1,3-beta-D-glucan synthase Fks1p S629P mutant/wild type Fks2pMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
Target1,3-beta-glucan synthase(Neosartorya fumigata)
Umdnj-New Jersey Medical School

Curated by ChEMBL
LigandPNGBDBM50478215(CHEBI:474180 | Cancidas | Caspofungin | Caspofungi...)
Affinity DataIC50: 110nMAssay Description:Inhibition of 1,3-beta-D-glucan synthase EMFR-S678P mutant from Aspergillus fumigatus assessed as incorporation of [3H]glucoseMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
Target1,3-beta-glucan synthase(Yeast)
University of Medicine and Dentistry of New Jersey

Curated by ChEMBL
LigandPNGBDBM50478215(CHEBI:474180 | Cancidas | Caspofungin | Caspofungi...)
Affinity DataIC50: 698nMAssay Description:Inhibition of Candida glabrata isolate 42997 1,3-beta-D-glucan synthase Fks1p F625S mutant/wild type Fks2pMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
Target1,3-beta-glucan synthase(Yeast)
University of Medicine and Dentistry of New Jersey

Curated by ChEMBL
LigandPNGBDBM50478215(CHEBI:474180 | Cancidas | Caspofungin | Caspofungi...)
Affinity DataIC50: 756nMAssay Description:Inhibition of Candida glabrata isolate 21900 1,3-beta-D-glucan synthase Fks1p D632G mutant/wild type Fks2pMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
Target1,3-beta-glucan synthase(Yeast)
University of Medicine and Dentistry of New Jersey

Curated by ChEMBL
LigandPNGBDBM50478215(CHEBI:474180 | Cancidas | Caspofungin | Caspofungi...)
Affinity DataIC50: 845nMAssay Description:Inhibition of Candida glabrata isolate 3169 1,3-beta-D-glucan synthase Fks1p D632E mutant/wild type Fks2pMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
Target1,3-beta-glucan synthase(Yeast)
University of Medicine and Dentistry of New Jersey

Curated by ChEMBL
LigandPNGBDBM50478215(CHEBI:474180 | Cancidas | Caspofungin | Caspofungi...)
Affinity DataIC50: 115nMAssay Description:Inhibition of Candida glabrata isolate 234 1,3-beta-D-glucan synthase wild type Fks1p/Fks2p F659V mutantMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
Target1,3-beta-glucan synthase(Yeast)
University of Medicine and Dentistry of New Jersey

Curated by ChEMBL
LigandPNGBDBM50478215(CHEBI:474180 | Cancidas | Caspofungin | Caspofungi...)
Affinity DataIC50: 5.12E+3nMAssay Description:Inhibition of Candida glabrata isolate 3830 1,3-beta-D-glucan synthase wild type Fks1p/Fks2p S663P mutantMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
Target1,3-beta-glucan synthase(Yeast)
University of Medicine and Dentistry of New Jersey

Curated by ChEMBL
LigandPNGBDBM50478215(CHEBI:474180 | Cancidas | Caspofungin | Caspofungi...)
Affinity DataIC50: 258nMAssay Description:Inhibition of Candida glabrata isolate 42031 1,3-beta-D-glucan synthase wild type Fks1p/Fks2p D666E mutantMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
Target1,3-beta-glucan synthase(Yeast)
University of Medicine and Dentistry of New Jersey

Curated by ChEMBL
LigandPNGBDBM50478215(CHEBI:474180 | Cancidas | Caspofungin | Caspofungi...)
Affinity DataIC50: 166nMAssay Description:Inhibition of Candida glabrata isolate 51916 1,3-beta-D-glucan synthase wild type Fks1p/Fks2p P667T mutantMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
Target1,3-beta-glucan synthase(Yeast)
University of Medicine and Dentistry of New Jersey

Curated by ChEMBL
LigandPNGBDBM50478215(CHEBI:474180 | Cancidas | Caspofungin | Caspofungi...)
Affinity DataIC50: 608nMAssay Description:Inhibition of Candida glabrata isolate 5416 1,3-beta-D-glucan synthase wild type Fks1p/Fks2p W1375L mutantMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
Target1,3-beta-D-glucan synthase catalytic subunit(Yeast)
University of Medicine and Dentistry of New Jersey

Curated by ChEMBL
LigandPNGBDBM50478215(CHEBI:474180 | Cancidas | Caspofungin | Caspofungi...)
Affinity DataIC50: 0.240nMAssay Description:Inhibition of wild type Candida albicans MY1055 1,3-beta-D-glucan synthase using UDP[6,3H]-glucose as substrate after 60 mins by liquid scintillation...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
Target1,3-beta-glucan synthase(Yeast)
University of Medicine and Dentistry of New Jersey

Curated by ChEMBL
LigandPNGBDBM50478215(CHEBI:474180 | Cancidas | Caspofungin | Caspofungi...)
Affinity DataIC50: 507nMAssay Description:Inhibition of Candida glabrata isolate 41400 1,3-beta-D-glucan synthase wild type Fks1p/Fks2p D666G mutantMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
Target1,3-beta-glucan synthase(Yeast)
University of Medicine and Dentistry of New Jersey

Curated by ChEMBL
LigandPNGBDBM50478215(CHEBI:474180 | Cancidas | Caspofungin | Caspofungi...)
Affinity DataIC50: 1.06E+3nMAssay Description:Inhibition of Candida glabrata isolate 41026 1,3-beta-D-glucan synthase wild type Fks1p/Fks2p F659S mutantMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
Target1,3-beta-glucan synthase(Yeast)
Public Health Research Institute

Curated by ChEMBL
LigandPNGBDBM50478215(CHEBI:474180 | Cancidas | Caspofungin | Caspofungi...)
Affinity DataIC50: 0.300nMAssay Description:Inhibition of glucan synthase in Candida albicans ATCC 90028More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
Target1,3-beta-glucan synthase(Yeast)
Public Health Research Institute

Curated by ChEMBL
LigandPNGBDBM50478215(CHEBI:474180 | Cancidas | Caspofungin | Caspofungi...)
Affinity DataIC50: 1.30nMAssay Description:Inhibition of glucan synthase in Candida albicans ATCC 90028 in presence of 10% human serumMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
Target1,3-beta-glucan synthase(Yeast)
Public Health Research Institute

Curated by ChEMBL
LigandPNGBDBM50478215(CHEBI:474180 | Cancidas | Caspofungin | Caspofungi...)
Affinity DataIC50: 6.30nMAssay Description:Inhibition of glucan synthase in Candida albicans ATCC 90028 in presence of 50% human serumMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
Target1,3-beta-glucan synthase(Yeast)
Public Health Research Institute

Curated by ChEMBL
LigandPNGBDBM50478215(CHEBI:474180 | Cancidas | Caspofungin | Caspofungi...)
Affinity DataIC50: 2.80nMAssay Description:Inhibition of glucan synthase in Candida albicans ATCC 36082 in presence of 10% human serumMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
Target1,3-beta-glucan synthase(Yeast)
Public Health Research Institute

Curated by ChEMBL
LigandPNGBDBM50478215(CHEBI:474180 | Cancidas | Caspofungin | Caspofungi...)
Affinity DataIC50: 5.30nMAssay Description:Inhibition of glucan synthase in Candida albicans ATCC 36082 in presence of 20% human serumMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
Target1,3-beta-glucan synthase(Yeast)
Public Health Research Institute

Curated by ChEMBL
LigandPNGBDBM50478215(CHEBI:474180 | Cancidas | Caspofungin | Caspofungi...)
Affinity DataIC50: 8.70nMAssay Description:Inhibition of glucan synthase in Candida albicans ATCC 36082 in presence of 50% human serumMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed