BDBM504793 2-(isoxazol- 5-ylmethoxy)- 4-[5- (trifluoro- methyl)- 1,2,4-oxa- diazol-3- yl]pyridine::US11066396, Example 207

SMILES FC(F)(F)c1nc(no1)-c1ccnc(OCc2ccno2)c1

InChI Key InChIKey=XZDWUGCDCKHWQW-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 504793   

TargetHistone deacetylase 6(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM504793(2-(isoxazol- 5-ylmethoxy)- 4-[5- (trifluoro- methy...)
Affinity DataIC50: 23nMAssay Description:HDAC1 and 6 reagents: FLAG-tagged HDACs 1 and 6 were prepared in-house by protein expression in HEK293F cells followed by anti-FLAG affinity purifica...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2021
Entry Details
US Patent

TargetHistone deacetylase 8(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM504793(2-(isoxazol- 5-ylmethoxy)- 4-[5- (trifluoro- methy...)
Affinity DataIC50: 1.30E+3nMAssay Description:HDAC8 reagents: HDAC8 was purchased from Enzo Life Sciences [catalog #BML-SE145]. Assays were performed with buffer containing 20 mM HEPES, pH 8.0 [B...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2021
Entry Details
US Patent

TargetHistone deacetylase 1(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM504793(2-(isoxazol- 5-ylmethoxy)- 4-[5- (trifluoro- methy...)
Affinity DataIC50: 1.50E+3nMAssay Description:HDAC1 and 6 reagents: FLAG-tagged HDACs 1 and 6 were prepared in-house by protein expression in HEK293F cells followed by anti-FLAG affinity purifica...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2021
Entry Details
US Patent