BDBM50480673 Isentress::Isentress hd::MK-0518::MK-0518 POTASSIUM::MK0518 POTASSIUM::Raltegravir Potassium::Raltegravir monopotassium salt

SMILES Cc1nnc(o1)C(=O)NC(C)(C)c1nc(C(=O)NCc2ccc(F)cc2)c([O-])c(=O)n1C

InChI Key InChIKey=CZFFBEXEKNGXKS-UHFFFAOYSA-M

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50480673   

TargetIntegrase(Human immunodeficiency virus type 1)
Shionogi

Curated by ChEMBL
LigandPNGBDBM50480673(Isentress | Isentress hd | MK-0518 | MK-0518 POTAS...)
Affinity DataIC50: 3.30nMAssay Description:Inhibition of strand transfer activity of Human immunodeficiency virus 1 Integrase using [3H]labeled target DNA as substrate after 45 mins by scintil...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/29/2020
Entry Details Article
PubMed
TargetIntegrase(Human immunodeficiency virus type 1)
Shionogi

Curated by ChEMBL
LigandPNGBDBM50480673(Isentress | Isentress hd | MK-0518 | MK-0518 POTAS...)
Affinity DataIC50: 15nMAssay Description:Inhibition of HIV1 recombinant integrase strand transfer activity treated after enzyme assembly and washingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/27/2020
Entry Details Article
PubMed
TargetIntegrase(Human immunodeficiency virus type 1)
Shionogi

Curated by ChEMBL
LigandPNGBDBM50480673(Isentress | Isentress hd | MK-0518 | MK-0518 POTAS...)
Affinity DataIC50: 130nMAssay Description:Inhibition of HIV1 integrase 3'-strand transferMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/28/2020
Entry Details Article
PubMed