BDBM504888 2-{[(3- cyclopropyl- 1,2,4-oxa- diazol-5- yl)oxy] methyl}-5- [5-(trifluoro- methyl)- 1,2,4-oxa- diazol-3- yl]pyridine::US11066396, Example 296

SMILES FC(F)(F)c1nc(no1)-c1ccc(COc2nc(no2)C2CC2)nc1

InChI Key InChIKey=ZRYLLFLLUPIWJK-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 504888   

TargetHistone deacetylase 5(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM504888(2-{[(3- cyclopropyl- 1,2,4-oxa- diazol-5- yl)oxy] ...)
Affinity DataIC50: 49nMAssay Description:HDAC5 reagents: N-terminal GST tagged HDAC5 was purchased from BPS Bioscience [catalog #50045]. Assays were performed with buffer containing 20 mM HE...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2021
Entry Details
US Patent

TargetHistone deacetylase 6(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM504888(2-{[(3- cyclopropyl- 1,2,4-oxa- diazol-5- yl)oxy] ...)
Affinity DataIC50: 77nMAssay Description:HDAC1 and 6 reagents: FLAG-tagged HDACs 1 and 6 were prepared in-house by protein expression in HEK293F cells followed by anti-FLAG affinity purifica...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2021
Entry Details
US Patent

TargetHistone deacetylase 1(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM504888(2-{[(3- cyclopropyl- 1,2,4-oxa- diazol-5- yl)oxy] ...)
Affinity DataIC50: 3.70E+3nMAssay Description:HDAC1 and 6 reagents: FLAG-tagged HDACs 1 and 6 were prepared in-house by protein expression in HEK293F cells followed by anti-FLAG affinity purifica...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2021
Entry Details
US Patent