BDBM50506048 CHEMBL4513808
SMILES Cc1c(nc(C2CC2)n1-c1c(Cl)ccc(N2CC3(CC(C3)C(O)=O)C2)c1Cl)C1(CC1)C(F)(F)F
InChI Key InChIKey=ATOAVZQFLCOJQE-UHFFFAOYSA-N
Data 15 IC50
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 15 hits for monomerid = 50506048
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of Gal4-tagged RORbeta LBD (unknown origin) by cell based luciferase reporter gene assayMore data for this Ligand-Target Pair
Affinity DataIC50: 151nMAssay Description:Inhibition of Gal4-tagged RORgammat LBD (unknown origin) by cell based luciferase reporter gene assayMore data for this Ligand-Target Pair
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of Gal4-tagged RORalpha LBD (unknown origin) by cell based luciferase reporter gene assayMore data for this Ligand-Target Pair
TargetRetinoic acid receptor RXR-alpha(Homo sapiens (Human))
Global Discovery Chemistry
Curated by ChEMBL
Global Discovery Chemistry
Curated by ChEMBL
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of Gal4-tagged RXRalpha LBD (unknown origin) by cell based luciferase reporter gene assayMore data for this Ligand-Target Pair
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of Gal4-tagged ERalpha LBD (unknown origin) by cell based luciferase reporter gene assayMore data for this Ligand-Target Pair
TargetNuclear receptor subfamily 1 group I member 2(Homo sapiens (Human))
Global Discovery Chemistry
Curated by ChEMBL
Global Discovery Chemistry
Curated by ChEMBL
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of Gal4-tagged PXR LBD (unknown origin) by cell based luciferase reporter gene assayMore data for this Ligand-Target Pair
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of Gal4-tagged GR LBD (unknown origin) by cell based luciferase reporter gene assayMore data for this Ligand-Target Pair
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of Gal4-tagged VDR LBD (unknown origin) by cell based luciferase reporter gene assayMore data for this Ligand-Target Pair
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of Gal4-tagged PR LBD (unknown origin) by cell based luciferase reporter gene assayMore data for this Ligand-Target Pair
Affinity DataIC50: 151nMAssay Description:Inhibition of human GAL4-DBD fused RORgammat LBD expressed in human Jurkat cells assessed as inhibition of receptor transactivation after 24 hrs by l...More data for this Ligand-Target Pair
Affinity DataIC50: 1.34E+3nMAssay Description:Inverse agonist activity at RORgammat in human whole blood assessed as reduction in Con A/IL-23-stimulated IL-17 secretion after 72 hrs by ELISAMore data for this Ligand-Target Pair
Affinity DataIC50: 70nMAssay Description:Inhibition of human full-length eGFP-tagged RORgammat expressed in human HUT78 T-cells assessed as inhibition of PMA/CD3 monoclonal antibody stimulat...More data for this Ligand-Target Pair
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of Gal4-tagged FXR LBD (unknown origin) by cell based luciferase reporter gene assayMore data for this Ligand-Target Pair
TargetPeroxisome proliferator-activated receptor gamma(Homo sapiens (Human))
Global Discovery Chemistry
Curated by ChEMBL
Global Discovery Chemistry
Curated by ChEMBL
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of Gal4-tagged PPARgamma LBD (unknown origin) by cell based luciferase reporter gene assayMore data for this Ligand-Target Pair
Affinity DataIC50: 5nMAssay Description:Displacement of RIP140 cofactor peptide from human His6-tagged RORgammat LBD (264 to 518 residues) by TR-FRET assayMore data for this Ligand-Target Pair