BDBM50508920 CHEMBL4475004

SMILES COc1cc2cn[nH]c2cc1-c1ccc(F)c2c(N)c(cnc12)C(N)=O

InChI Key InChIKey=RFCJOYPMBVRHBV-UHFFFAOYSA-N

Data  8 IC50  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 9 hits for monomerid = 50508920   

TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
Tsinghua University

Curated by ChEMBL
LigandPNGBDBM50508920(CHEMBL4475004)
Affinity DataIC50:  5.30nMAssay Description:Reversible inhibition of FAM-labeled peptide binding to full-length human N-terminal GST-tagged BTK (2 to 659 residues) expressed in baculovirus infe...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
Tsinghua University

Curated by ChEMBL
LigandPNGBDBM50508920(CHEMBL4475004)
Affinity DataEC50:  43nMAssay Description:Reversible inhibition of sodium orthovanadate-stimulated BTK autophosphorylation at Tyr223 residues in human Ramos cells preincubated for 2 hrs follo...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Tec(Homo sapiens (Human))
Tsinghua University

Curated by ChEMBL
LigandPNGBDBM50508920(CHEMBL4475004)
Affinity DataIC50:  227nMAssay Description:Inhibition of recombinant human N-terminal GST-fused TEC catalytic domain (359 to 631 residues) expressed in baculovirus expression system using biot...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase ITK/TSK(Homo sapiens (Human))
Tsinghua University

Curated by ChEMBL
LigandPNGBDBM50508920(CHEMBL4475004)
Affinity DataIC50:  307nMAssay Description:Inhibition of recombinant human ITK (352 to 617 residues) using myelin basic protein as substrate measured after 40 mins in presence of [gamma33P]ATP...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Tsinghua University

Curated by ChEMBL
LigandPNGBDBM50508920(CHEMBL4475004)
Affinity DataIC50: >2.00E+3nMAssay Description:Inhibition of recombinant human GST-tagged EGFR cytoplasmic domain (668 to 1210 residues) expressed in baculovirus expression system using Z'-lyte-la...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Yes(Homo sapiens (Human))
Tsinghua University

Curated by ChEMBL
LigandPNGBDBM50508920(CHEMBL4475004)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of human full-length recombinant YES using poly(Glu, Tyr) 4:1 as substrate measured after 40 mins in presence of [gamma-33P]-ATP by scinti...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
Tsinghua University

Curated by ChEMBL
LigandPNGBDBM50508920(CHEMBL4475004)
Affinity DataIC50:  39nMAssay Description:Reversible inhibition of FAM-labeled peptide binding to full-length human N-terminal GST-tagged BTK C481S mutant (2 to 659 residues) expressed in bac...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Fyn(Homo sapiens (Human))
Tsinghua University

Curated by ChEMBL
LigandPNGBDBM50508920(CHEMBL4475004)
Affinity DataIC50:  165nMAssay Description:Inhibition of human full-length recombinant FYN using KVEKIGEGTYGVVYK as substrate measured after 40 mins in presence of [gamma-33P]-ATP by scintilla...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetProto-oncogene tyrosine-protein kinase Src(Homo sapiens (Human))
Tsinghua University

Curated by ChEMBL
LigandPNGBDBM50508920(CHEMBL4475004)
Affinity DataIC50:  903nMAssay Description:Inhibition of recombinant full-length human SRC using KVEKIGEGTYGVVYK as substrate measured after 40 mins in presence of [gamma33P]ATP by scintillati...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed