BDBM505095 N-({2- fluoro-4-[5- (trifluoro- methyl)- 1,2,4-oxa- diazol-3- yl]phenyl} methyl)- 1,1-dioxo- N-[3- (trifluoro- methyl) phenyl]- llambda ~6~-thiane- 4-carbox- amide::US11066396, Example 490

SMILES Fc1cc(ccc1CN(C(=O)C1CCS(=O)(=O)CC1)c1cccc(c1)C(F)(F)F)-c1noc(n1)C(F)(F)F

InChI Key InChIKey=CCIJLJKNTRABLI-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 505095   

TargetHistone deacetylase 6(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM505095(N-({2- fluoro-4-[5- (trifluoro- methyl)- 1,2,4-oxa...)
Affinity DataIC50: 18nMAssay Description:HDAC1 and 6 reagents: FLAG-tagged HDACs 1 and 6 were prepared in-house by protein expression in HEK293F cells followed by anti-FLAG affinity purifica...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2021
Entry Details
Go to US Patent

TargetHistone deacetylase 1(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM505095(N-({2- fluoro-4-[5- (trifluoro- methyl)- 1,2,4-oxa...)
Affinity DataIC50: 500nMAssay Description:HDAC1 and 6 reagents: FLAG-tagged HDACs 1 and 6 were prepared in-house by protein expression in HEK293F cells followed by anti-FLAG affinity purifica...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2021
Entry Details
Go to US Patent

TargetHistone deacetylase 5(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM505095(N-({2- fluoro-4-[5- (trifluoro- methyl)- 1,2,4-oxa...)
Affinity DataIC50: 520nMAssay Description:HDAC5 reagents: N-terminal GST tagged HDAC5 was purchased from BPS Bioscience [catalog #50045]. Assays were performed with buffer containing 20 mM HE...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2021
Entry Details
Go to US Patent

TargetHistone deacetylase 8(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM505095(N-({2- fluoro-4-[5- (trifluoro- methyl)- 1,2,4-oxa...)
Affinity DataIC50: 3.40E+3nMAssay Description:HDAC8 reagents: HDAC8 was purchased from Enzo Life Sciences [catalog #BML-SE145]. Assays were performed with buffer containing 20 mM HEPES, pH 8.0 [B...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2021
Entry Details
Go to US Patent