BDBM50511566 CHEMBL4448872

SMILES OCCN1CC2(CCN(CC2)c2nc3CCCCc3c(=O)[nH]2)c2c1cc(F)cc2F

InChI Key InChIKey=FZQYCOUBRJEYBC-UHFFFAOYSA-N

Data  20 IC50

PDB links: 1 PDB ID matches this monomer.

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 20 hits for monomerid = 50511566   

TargetPoly [ADP-ribose] polymerase tankyrase-1/tankyrase-2(Homo sapiens (Human))
Riken

Curated by ChEMBL

LigandBDBM50511566(CHEMBL4448872)Copy SMILESCopy InChI

Affinity DataIC50:  78nMAssay Description:Inhibition of TNKS/TNKS2 (unknown origin) expressed in human DLD1 cells assessed as reduction in Wnt-signaling measured after 24 hrs by TCF-luciferas...More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
antibodypediaantibodypediaGoogleScholar

Ligand InfoPurchasePC cidPC sidPDB

In DepthDetails ArticlePubMedPDB3D Structure (crystal)
Copy BDB DOI

TargetPoly [ADP-ribose] polymerase tankyrase-2(Homo sapiens (Human))TBA

LigandBDBM50511566(CHEMBL4448872)Copy SMILESCopy InChI

Affinity DataIC50:  11nMAssay Description:Inhibition of human recombinant TNKS2More data for this Ligand-Target Pair

Target InfoPDBReactome pathway
UniProtKB/SwissProt
antibodypediaGoogleScholar

Ligand InfoPurchasePC cidPC sidPDB

In DepthDetails PubMedPDB3D Structure (crystal)
Copy BDB DOI

TargetProtein mono-ADP-ribosyltransferase PARP10(Homo sapiens (Human))
Riken

Curated by ChEMBL

LigandBDBM50511566(CHEMBL4448872)Copy SMILESCopy InChI

Affinity DataIC50:  1.98E+4nMAssay Description:Inhibition of human recombinant N-terminal TEV-cleavgae site-fused-FLAG/Polyhis-tagged PARP10 (2 to 583 residues) expressed in Escherichia coli asses...More data for this Ligand-Target Pair

Target InfoPDBReactome pathway
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPurchasePC cidPC sidPDB

In DepthDetails ArticlePubMed
Copy BDB DOI

TargetPoly [ADP-ribose] polymerase tankyrase-2(Homo sapiens (Human))TBA

LigandBDBM50511566(CHEMBL4448872)Copy SMILESCopy InChI

Affinity DataIC50:  11nMAssay Description:Inhibition of recombinant human N-terminal TEV cleavage site-fused/FLAG-poly his-tagged TNKS2 SAM-PARP domain (613 to 1166 residues) expressed in Esc...More data for this Ligand-Target Pair

Target InfoPDBReactome pathway
UniProtKB/SwissProt
antibodypediaGoogleScholar

Ligand InfoPurchasePC cidPC sidPDB

In DepthDetails ArticlePubMedPDB3D Structure (crystal)
Copy BDB DOI

TargetPoly [ADP-ribose] polymerase tankyrase-1/tankyrase-2(Homo sapiens (Human))
Riken

Curated by ChEMBL

LigandBDBM50511566(CHEMBL4448872)Copy SMILESCopy InChI

Affinity DataIC50:  12nMAssay Description:Inhibition of TNKS/TNKS2 (unknown origin) expressed in HEK293 cells assessed as reduction in Wnt-signaling measured after 24 hrs by TCF-luciferase re...More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
antibodypediaantibodypediaGoogleScholar

Ligand InfoPurchasePC cidPC sidPDB

In DepthDetails ArticlePubMedPDB3D Structure (crystal)
Copy BDB DOI

TargetPoly [ADP-ribose] polymerase tankyrase-1(Homo sapiens (Human))
Riken

Curated by ChEMBL

LigandBDBM50511566(CHEMBL4448872)Copy SMILESCopy InChI

Affinity DataIC50:  14nMAssay Description:Inhibition of recombinant human N-terminal TEV cleavage site-fused/FLAG-poly his-tagged TNKS SAM-PARP domain (1024 to 1327 residues) expressed in Esc...More data for this Ligand-Target Pair

Target InfoPDBReactome pathway
UniProtKB/SwissProt
antibodypediaGoogleScholar

Ligand InfoPurchasePC cidPC sidPDB

In DepthDetails ArticlePubMedPDB3D Structure (crystal)
Copy BDB DOI

TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
Riken

Curated by ChEMBL

LigandBDBM50511566(CHEMBL4448872)Copy SMILESCopy InChI

Affinity DataIC50: >2.00E+4nMAssay Description:Inhibition of recombinant human PARP1 expressed in Escherichia coli assessed as reduction in auto-PARylation using histone as substrate measured afte...More data for this Ligand-Target Pair

Target InfoPDBMMDBReactome pathway
UniProtKB/SwissProt
B.MOADantibodypediaGoogleScholar

Ligand InfoPurchasePC cidPC sidPDB

In DepthDetails ArticlePubMed
Copy BDB DOI

TargetPoly [ADP-ribose] polymerase tankyrase-1/tankyrase-2(Homo sapiens (Human))
Riken

Curated by ChEMBL

LigandBDBM50511566(CHEMBL4448872)Copy SMILESCopy InChI

Affinity DataIC50:  12nMAssay Description:Inhibition of TNKS/TNKS2 (unknown origin) expressed in HEK293 cells assessed as reduction in Wnt-signaling measured after 24 hrs by TCF-luciferase re...More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
antibodypediaantibodypediaGoogleScholar

Ligand InfoPurchasePC cidPC sidPDB

In DepthDetails ArticlePubMedPDB3D Structure (crystal)
Copy BDB DOI

TargetPoly [ADP-ribose] polymerase tankyrase-1/tankyrase-2(Homo sapiens (Human))
Riken

Curated by ChEMBL

LigandBDBM50511566(CHEMBL4448872)Copy SMILESCopy InChI

Affinity DataIC50:  78nMAssay Description:Inhibition of TNKS/TNKS2 (unknown origin) expressed in human DLD1 cells assessed as reduction in Wnt-signaling measured after 24 hrs by TCF-luciferas...More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
antibodypediaantibodypediaGoogleScholar

Ligand InfoPurchasePC cidPC sidPDB

In DepthDetails ArticlePubMedPDB3D Structure (crystal)
Copy BDB DOI

TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
Riken

Curated by ChEMBL

LigandBDBM50511566(CHEMBL4448872)Copy SMILESCopy InChI

Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of recombinant human PARP1 expressed in Escherichia coli assessed as reduction in auto-PARylation using histone as substrate measured afte...More data for this Ligand-Target Pair

Target InfoPDBMMDBReactome pathway
UniProtKB/SwissProt
B.MOADantibodypediaGoogleScholar

Ligand InfoPurchasePC cidPC sidPDB

In DepthDetails ArticlePubMed
Copy BDB DOI

TargetPoly [ADP-ribose] polymerase tankyrase-2(Homo sapiens (Human))TBA

LigandBDBM50511566(CHEMBL4448872)Copy SMILESCopy InChI

Affinity DataIC50:  11nMAssay Description:Inhibition of recombinant human N-terminal TEV cleavage site-fused/FLAG-poly his-tagged TNKS2 ARC5-SAM-PARP domain (613 to 1166 residues) expressed i...More data for this Ligand-Target Pair

Target InfoPDBReactome pathway
UniProtKB/SwissProt
antibodypediaGoogleScholar

Ligand InfoPurchasePC cidPC sidPDB

In DepthDetails ArticlePubMedPDB3D Structure (crystal)
Copy BDB DOI

TargetPoly [ADP-ribose] polymerase 2(Homo sapiens (Human))
Japanese Foundation For Cancer Research

Curated by ChEMBL

LigandBDBM50511566(CHEMBL4448872)Copy SMILESCopy InChI

Affinity DataIC50:  2.72E+3nMAssay Description:Inhibition of human recombinant N-terminal GST-tagged PARP2 (2 to 583 residues) expressed in baculovirus infected Sf9 cells assessed as reduction in ...More data for this Ligand-Target Pair

Target InfoPDBReactome pathwayKEGG
UniProtKB/SwissProt
B.MOADDrugBankantibodypediaGoogleScholar

Ligand InfoPurchasePC cidPC sidPDB

In DepthDetails ArticlePubMed
Copy BDB DOI

TargetProtein mono-ADP-ribosyltransferase PARP10(Homo sapiens (Human))
Riken

Curated by ChEMBL

LigandBDBM50511566(CHEMBL4448872)Copy SMILESCopy InChI

Affinity DataIC50:  1.98E+4nMAssay Description:Inhibition of human recombinant N-terminal TEV-cleavgae site-fused-FLAG/Polyhis-tagged PARP10 (2 to 583 residues) expressed in Escherichia coli asses...More data for this Ligand-Target Pair

Target InfoPDBReactome pathway
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPurchasePC cidPC sidPDB

In DepthDetails ArticlePubMed
Copy BDB DOI

TargetPoly [ADP-ribose] polymerase tankyrase-1(Homo sapiens (Human))
Riken

Curated by ChEMBL

LigandBDBM50511566(CHEMBL4448872)Copy SMILESCopy InChI

Affinity DataIC50:  14nMAssay Description:Inhibition of recombinant human N-terminal TEV cleavage site-fused/FLAG-poly his-tagged TNKS SAM-PARP domain (1024 to 1327 residues) expressed in Esc...More data for this Ligand-Target Pair

Target InfoPDBReactome pathway
UniProtKB/SwissProt
antibodypediaGoogleScholar

Ligand InfoPurchasePC cidPC sidPDB

In DepthDetails ArticlePubMedPDB3D Structure (crystal)
Copy BDB DOI

TargetPoly [ADP-ribose] polymerase tankyrase-1(Homo sapiens (Human))
Riken

Curated by ChEMBL

LigandBDBM50511566(CHEMBL4448872)Copy SMILESCopy InChI

Affinity DataIC50:  14nMAssay Description:Inhibition of TNKS1 (unknown origin)More data for this Ligand-Target Pair

Target InfoPDBReactome pathway
UniProtKB/SwissProt
antibodypediaGoogleScholar

Ligand InfoPurchasePC cidPC sidPDB

In DepthDetails PubMedPDB3D Structure (crystal)
Copy BDB DOI

TargetPoly [ADP-ribose] polymerase tankyrase-2(Homo sapiens (Human))TBA

LigandBDBM50511566(CHEMBL4448872)Copy SMILESCopy InChI

Affinity DataIC50:  11nMAssay Description:Inhibition of TNKS2 (unknown origin)More data for this Ligand-Target Pair

Target InfoPDBReactome pathway
UniProtKB/SwissProt
antibodypediaGoogleScholar

Ligand InfoPurchasePC cidPC sidPDB

In DepthDetails PubMedPDB3D Structure (crystal)
Copy BDB DOI

TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
Riken

Curated by ChEMBL

LigandBDBM50511566(CHEMBL4448872)Copy SMILESCopy InChI

Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of PARP1 (unknown origin)More data for this Ligand-Target Pair

Target InfoPDBMMDBReactome pathway
UniProtKB/SwissProt
B.MOADantibodypediaGoogleScholar

Ligand InfoPurchasePC cidPC sidPDB

In DepthDetails PubMed
Copy BDB DOI

TargetPoly [ADP-ribose] polymerase 2(Homo sapiens (Human))
Japanese Foundation For Cancer Research

Curated by ChEMBL

LigandBDBM50511566(CHEMBL4448872)Copy SMILESCopy InChI

Affinity DataIC50:  2.72E+3nMAssay Description:Inhibition of PAPR2 (unknown origin)More data for this Ligand-Target Pair

Target InfoPDBReactome pathwayKEGG
UniProtKB/SwissProt
B.MOADDrugBankantibodypediaGoogleScholar

Ligand InfoPurchasePC cidPC sidPDB

In DepthDetails PubMed
Copy BDB DOI

TargetPoly [ADP-ribose] polymerase tankyrase-1(Homo sapiens (Human))
Riken

Curated by ChEMBL

LigandBDBM50511566(CHEMBL4448872)Copy SMILESCopy InChI

Affinity DataIC50:  14nMAssay Description:Inhibition of human recombinant TNKS1More data for this Ligand-Target Pair

Target InfoPDBReactome pathway
UniProtKB/SwissProt
antibodypediaGoogleScholar

Ligand InfoPurchasePC cidPC sidPDB

In DepthDetails PubMedPDB3D Structure (crystal)
Copy BDB DOI

TargetPoly [ADP-ribose] polymerase 2(Homo sapiens (Human))
Japanese Foundation For Cancer Research

Curated by ChEMBL

LigandBDBM50511566(CHEMBL4448872)Copy SMILESCopy InChI

Affinity DataIC50:  2.72E+3nMAssay Description:Inhibition of human recombinant N-terminal GST-tagged PARP2 (2 to 583 residues) expressed in baculovirus infected Sf9 cells assessed as reduction in ...More data for this Ligand-Target Pair

Target InfoPDBReactome pathwayKEGG
UniProtKB/SwissProt
B.MOADDrugBankantibodypediaGoogleScholar

Ligand InfoPurchasePC cidPC sidPDB

In DepthDetails ArticlePubMed
Copy BDB DOI