BDBM50519291 CHEMBL4462495::US20240059675, Compound SEN177::US20240101544, Example SEN177

SMILES Cn1cnnc1C1CCN(CC1)c1ncccc1-c1ccc(F)nc1

InChI Key InChIKey=AJIAMIPUWJQSPR-UHFFFAOYSA-N

Data  2 KI  8 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 10 hits for monomerid = 50519291   

TargetGlutaminyl-peptide cyclotransferase(Human)
Sichuan University

Curated by ChEMBL
LigandPNGBDBM50519291(CHEMBL4462495 | US20240059675, Compound SEN177 | U...)
Affinity DataIC50: 0.0530nMAssay Description:Inhibition of sQC (unknown origin) expressed in Escherichia coli Transetta (DE3) assessed as N-terminal pyroglutamate formation using fluorescent sub...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetGlutaminyl-peptide cyclotransferase-like protein(Human)
Sichuan University

Curated by ChEMBL
LigandPNGBDBM50519291(CHEMBL4462495 | US20240059675, Compound SEN177 | U...)
Affinity DataIC50: 13nMAssay Description:Inhibition of gQC (unknown origin) expressed in Escherichia coli Transetta (DE3) assessed as N-terminal pyroglutamate formation using fluorescent sub...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetGlutaminyl-peptide cyclotransferase(Human)
Sichuan University

Curated by ChEMBL
LigandPNGBDBM50519291(CHEMBL4462495 | US20240059675, Compound SEN177 | U...)
Affinity DataIC50: 17nMAssay Description:Inhibition of human recombinant glutaminyl cyclase using H-Gln-AMC hydrobromide as substrate measured after 15 mins by fluorimetryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/5/2023
Entry Details Article
PubMed
TargetGlutaminyl-peptide cyclotransferase-like protein(Human)
Sichuan University

Curated by ChEMBL
LigandPNGBDBM50519291(CHEMBL4462495 | US20240059675, Compound SEN177 | U...)
Affinity DataIC50: 17nMAssay Description:QPCT or QPCTL dependent conversion of N-terminal glutamine to pyroglutamate of CD47 was monitored via MALDI-TOF MS. Test compounds were dissolved in ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/24/2024
Entry Details
Go to US Patent

TargetGlutaminyl-peptide cyclotransferase(Human)
Sichuan University

Curated by ChEMBL
LigandPNGBDBM50519291(CHEMBL4462495 | US20240059675, Compound SEN177 | U...)
Affinity DataIC50: 17nMAssay Description:Inhibition of recombinant human N-terminal His6-tagged glutaminyl cyclase (Ala33 to Leu361 residues) expressed in baculovirus infected Sf21 insect ce...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
TargetGlutaminyl-peptide cyclotransferase(Human)
Sichuan University

Curated by ChEMBL
LigandPNGBDBM50519291(CHEMBL4462495 | US20240059675, Compound SEN177 | U...)
Affinity DataKi:  20nMAssay Description:Inhibition of human glutaminyl cyclase assessed as inhibition constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/18/2024
Entry Details
PubMed
TargetGlutaminyl-peptide cyclotransferase(Human)
Sichuan University

Curated by ChEMBL
LigandPNGBDBM50519291(CHEMBL4462495 | US20240059675, Compound SEN177 | U...)
Affinity DataKi:  20nMAssay Description:Binding affinity to human QC assessed as inhibition constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2024
Entry Details
PubMed
TargetGlutaminyl-peptide cyclotransferase(Human)
Sichuan University

Curated by ChEMBL
LigandPNGBDBM50519291(CHEMBL4462495 | US20240059675, Compound SEN177 | U...)
Affinity DataIC50: 79nMAssay Description:QPCT or QPCTL dependent conversion of N-terminal glutamine to pyroglutamate of CD47 was monitored via MALDI-TOF MS. Test compounds were dissolved in ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/24/2024
Entry Details
Go to US Patent

TargetGlutaminyl-peptide cyclotransferase(Human)
Sichuan University

Curated by ChEMBL
LigandPNGBDBM50519291(CHEMBL4462495 | US20240059675, Compound SEN177 | U...)
Affinity DataIC50: 100nMAssay Description:Compound IC50 values for the inhibition of QPCT (rhQPCT, R&D Systems) activity were determined using a biochemical fluorescent-based assay. QPCT acti...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/11/2024
Entry Details
Go to US Patent

TargetGlutaminyl-peptide cyclotransferase-like protein(Human)
Sichuan University

Curated by ChEMBL
LigandPNGBDBM50519291(CHEMBL4462495 | US20240059675, Compound SEN177 | U...)
Affinity DataIC50: 100nMAssay Description:Compound IC50 values for the inhibition of QPCTL activity were determined using a biochemical fluorescent-based assay. QPCTL activity was measured in...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/11/2024
Entry Details
Go to US Patent