BDBM50531188 CHEMBL1098291::Carnosic Acid Gamma-Lactone

SMILES [H][C@@]12CCc3cc(C(C)C)c(O)c4OC(=O)[C@@]1(CCCC2(C)C)c34

InChI Key InChIKey=HEHCCMUMPYGALS-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50531188   

TargetFarnesyl pyrophosphate synthase(Human)
Tsinghua University

Curated by ChEMBL
LigandPNGBDBM50531188(CHEMBL1098291 | Carnosic Acid Gamma-Lactone)
Affinity DataIC50: 1.06E+4nMAssay Description:Inhibition of human N-terminal TEV protease cleavage site-fused-His6-tagged FPPS expressed in Escherichia coli BL21 (DE3) using GPP and IPP as substr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMed
TargetFarnesyl pyrophosphate synthase(Human)
Tsinghua University

Curated by ChEMBL
LigandPNGBDBM50531188(CHEMBL1098291 | Carnosic Acid Gamma-Lactone)
Affinity DataIC50: 1.06E+4nMAssay Description:Inhibition of human N-terminal TEV protease cleavage site-fused-His6-tagged FPPS expressed in Escherichia coli BL21 (DE3) using GPP and IPP as substr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMed
TargetGeranylgeranyl pyrophosphate synthase(Human)
Tsinghua University

Curated by ChEMBL
LigandPNGBDBM50531188(CHEMBL1098291 | Carnosic Acid Gamma-Lactone)
Affinity DataIC50: 1.47E+4nMAssay Description:Inhibition of human N-terminal TEV protease cleavage site-fused-His6-tagged GGPPS expressed in Escherichia coli BL21 (DE3) using FPP and [14C] IPP as...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMed
TargetGeranylgeranyl pyrophosphate synthase(Human)
Tsinghua University

Curated by ChEMBL
LigandPNGBDBM50531188(CHEMBL1098291 | Carnosic Acid Gamma-Lactone)
Affinity DataIC50: 1.47E+4nMAssay Description:Inhibition of human N-terminal TEV protease cleavage site-fused-His6-tagged GGPPS expressed in Escherichia coli BL21 (DE3) using FPP and [14C] IPP as...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMed