BDBM50531783 CHEMBL4591892::US11530198, Example 87
SMILES Nc1ncc(N2CCN(CC2)c2cccc(c2)-c2cnc(nc2)C(F)(F)F)c(N)n1
InChI Key InChIKey=NUSOKJSAAFOUGX-UHFFFAOYSA-N
Data 4 IC50
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 4 hits for monomerid = 50531783
Affinity DataIC50: 2.80E+3nMAssay Description:Inhibition of human DHFR expressed in Escherichia coli BL21 competent cells using DHF as substrate preincubated for 15 mins followed by substrate and...More data for this Ligand-Target Pair
TargetBifunctional dihydrofolate reductase-thymidylate synthase(Trypanosoma brucei brucei)
Vyera Pharmaceuticals
US Patent
Vyera Pharmaceuticals
US Patent
TargetBifunctional dihydrofolate reductase-thymidylate synthase(Toxoplasma gondii)
Vyera Pharmaceuticals
Curated by ChEMBL
Vyera Pharmaceuticals
Curated by ChEMBL
Affinity DataIC50: 33nMAssay Description:Inhibition of Toxoplasma gondii DHFR-TS expressed in Escherichia coli BL21 competent cells using DHF as substrate preincubated for 15 mins followed b...More data for this Ligand-Target Pair