BDBM50539915 CHEMBL4643754::US11142507, Compound MFH-4-4-1

SMILES C=CC(=O)Nc1ccc(cc1)C(=O)N1CCC[C@H](C1)Nc1ncc(SCC2CCOCC2)s1

InChI Key InChIKey=XPTUNGFRXJHQJG-UHFFFAOYSA-N

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50539915   

TargetCyclin-dependent kinase 2(Human)
Dana-Farber Cancer Institute

US Patent
LigandChemical structure of BindingDB Monomer ID 50539915BDBM50539915(CHEMBL4643754 | US11142507, Compound MFH-4-4-1)
Affinity DataIC50: 1.00E+3nMAssay Description:Jurkat cells were treated with DMSO or concentration of compound indicated. 6 hours after treatment, cells were washed and harvested by resuspending ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/4/2022
Entry Details
US Patent

TargetCyclin-dependent kinase 7(Human)
Dana-Farber Cancer Institute

US Patent
LigandChemical structure of BindingDB Monomer ID 50539915BDBM50539915(CHEMBL4643754 | US11142507, Compound MFH-4-4-1)
Affinity DataIC50: 1.00E+3nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/4/2022
Entry Details
US Patent

TargetCyclin-dependent kinase 9(Human)
Dana-Farber Cancer Institute

US Patent
LigandChemical structure of BindingDB Monomer ID 50539915BDBM50539915(CHEMBL4643754 | US11142507, Compound MFH-4-4-1)
Affinity DataIC50: 1.00E+3nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/4/2022
Entry Details
US Patent

TargetCyclin-A1/Cyclin-dependent kinase 2(Human)
Harvard Medical School

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50539915BDBM50539915(CHEMBL4643754 | US11142507, Compound MFH-4-4-1)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of recombinant human full-length N-terminal GST-tagged CDK2/cyclinA1 expressed in baculovirus infected Sf9 insect cells using FRET-labeled...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/12/2021
Entry Details Article
PubMed
TargetCyclin-T1/Cyclin-dependent kinase 9(Human)
Harvard Medical School

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50539915BDBM50539915(CHEMBL4643754 | US11142507, Compound MFH-4-4-1)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of recombinant human full-length His-tagged CDK9/Cyclin T1 expressed in baculovirus infection system using Cdk7/9tide as substrate measure...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/12/2021
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50539915BDBM50539915(CHEMBL4643754 | US11142507, Compound MFH-4-4-1)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of recombinant human full-length His-tagged CDK7/Cyclin H/MNAT1 expressed in baculovirus infection system using Cdk7/9tide as substrate me...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/12/2021
Entry Details Article
PubMed