BDBM50546123 CHEMBL4789381

SMILES N[C@H]([C@@H](O)CN(Cc1ccccc1)S(=O)(=O)c1ccc(Cl)c(Cl)c1)c1ccccc1

InChI Key InChIKey=LGXZEBGEBDJZBV-VXKWHMMOSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50546123   

TargetPresenilin-1(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50546123(CHEMBL4789381)
Affinity DataIC50:  3.40E+3nMAssay Description:Inhibition of gamma-secretase (unknown origin) expressed in HEK293 cells cotransfected with Notch1-VP16-GAL4 fusion and Gal4 luciferase reporter plas...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSignal peptide peptidase-like 2A(Homo sapiens)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50546123(CHEMBL4789381)
Affinity DataIC50:  620nMAssay Description:Inhibition of human SPPL2a expressed in HEK293 cells cotransfected with Gal4 luciferase reporter plasmid and VP16-TNFalpha(1-76)-NTF incubated for 24...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed