BDBM50547007 CHEMBL4747960::US11752138, Compound 121

SMILES NS(=O)(=O)c1ccc(Cc2c(CC3CC3)n(nc2-c2cccc(c2)C#Cc2ccc(s2)C(F)F)-c2nc(cs2)C(O)=O)cc1F

InChI Key InChIKey=RNXRHVQQPAPBKD-UHFFFAOYSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50547007   

TargetL-lactate dehydrogenase B chain(Human)
Vanderbilt University

US Patent
LigandPNGBDBM50547007(CHEMBL4747960 | US11752138, Compound 121)
Affinity DataIC50: 100nMAssay Description:This example describes a human LDHB biochemical assay employed in the characterization of a compound of Formula I in an embodiment of the dislcosure....More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/20/2023
Entry Details
US Patent

TargetL-lactate dehydrogenase A chain(Human)
National Institutes of Health

Curated by ChEMBL
LigandPNGBDBM50547007(CHEMBL4747960 | US11752138, Compound 121)
Affinity DataIC50: 134nMAssay Description:Inhibition of GS[HiBiT]GS-tagged LDHA (unknown origin) expressed in HEK-293T cells measured after 1 hr by CESTAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/22/2022
Entry Details Article
PubMed
TargetL-lactate dehydrogenase A chain(Human)
National Institutes of Health

Curated by ChEMBL
LigandPNGBDBM50547007(CHEMBL4747960 | US11752138, Compound 121)
Affinity DataIC50: 154nMAssay Description:Inhibition of recombinant human LDHA using sodium pyruvate as substrate preincubated for 5 mins followed by diaphorase/resazurin addition and measure...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/22/2022
Entry Details Article
PubMed
TargetL-lactate dehydrogenase A chain(Human)
National Institutes of Health

Curated by ChEMBL
LigandPNGBDBM50547007(CHEMBL4747960 | US11752138, Compound 121)
Affinity DataIC50: 286nMAssay Description:Inhibition of LDHA in human MIA PaCa-2 cells assessed as decrease in lactate production incubated for 2 hrs by lactate oxidase-coupled fluorescence b...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/22/2022
Entry Details Article
PubMed
TargetL-lactate dehydrogenase A chain(Human)
National Institutes of Health

Curated by ChEMBL
LigandPNGBDBM50547007(CHEMBL4747960 | US11752138, Compound 121)
Affinity DataIC50: 345nMAssay Description:Inhibition of LDHA in human A673 cells assessed as decrease in lactate production incubated for 2 hrs by lactate oxidase-coupled fluorescence based a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/22/2022
Entry Details Article
PubMed