BDBM50554450 CHEMBL4760228::US11634391, Compound 196

SMILES FC(F)(F)c1cc(ccc1Cl)-c1nnco1

InChI Key InChIKey=WASVOWHKQQFANQ-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50554450   

TargetPalmitoleoyl-protein carboxylesterase NOTUM(Homo sapiens (Human))
Ucl Business

US Patent
LigandPNGBDBM50554450(CHEMBL4760228 | US11634391, Compound 196)
Affinity DataIC50:  16.6nMAssay Description:An Echo liquid handler was used to acoustically dispense 500 nL of compounds into dry Greiner 384-well plates (catalog #781076), followed by 25 μ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetPalmitoleoyl-protein carboxylesterase NOTUM(Homo sapiens (Human))
Ucl Business

US Patent
LigandPNGBDBM50554450(CHEMBL4760228 | US11634391, Compound 196)
Affinity DataIC50:  13nMAssay Description:Inhibition of human Notum (S81-T451 residues) C330S mutant expressed in HEK293S cells using OPTS substrate incubated for 40 mins by fluorescence base...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed