BDBM505627 (S)-8-chloro-4-((3-chloro-4- fluorophenyl)amino)-6-(((4,5,6,7- tetrahydrothieno[2,3-c]pyridin-3- yl)(1H-1,2,3-triazol-4-yl)methyl)- amino)quinoline-3-carbonitrile::US11066414, Compound 275

SMILES Fc1ccc(Nc2c(cnc3c(Cl)cc(N[C@H](C4=CNNN4)c4csc5CNCCc45)cc23)C#N)cc1Cl

InChI Key InChIKey=MNVAYFQCNYBKAU-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 505627   

TargetEpidermal growth factor receptor(Human)
Gilead Sciences

US Patent
LigandPNGBDBM505627(US11066414, Compound 275 | (S)-8-chloro-4-((3-chlo...)
Affinity DataIC50: 7nMAssay Description:EGFR activity was measured using KinEASE (Cisbio), a time-resolved fluorescence resonance energy transfer (TR-FRET) immunoassay. In this assay, EGFR-...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/23/2021
Entry Details
US Patent