BDBM50563915 CHEMBL4794949

SMILES CC(C)(C)c1cc(NC(=O)Nc2ccc(Nc3ncnc4NCCOc34)nc2)no1

InChI Key InChIKey=IURDYILFAJIFFW-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50563915   

TargetProto-oncogene tyrosine-protein kinase receptor Ret(Homo sapiens (Human))
Sichuan University/Collaborative Innovation Center Of Biotherapy

Curated by ChEMBL
LigandPNGBDBM50563915(CHEMBL4794949)
Affinity DataIC50:  54nMAssay Description:Inhibition of recombinant human RET V804L mutant using KKKVSRSGLYRSP as substrate incubated for 15 mins followed by Mg/ATP addition and measured afte...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetProto-oncogene tyrosine-protein kinase receptor Ret(Homo sapiens (Human))
Sichuan University/Collaborative Innovation Center Of Biotherapy

Curated by ChEMBL
LigandPNGBDBM50563915(CHEMBL4794949)
Affinity DataIC50:  77nMAssay Description:Inhibition of recombinant human RET using KKKSPGEYVNIEFG as substrate incubated for 15 mins followed by Mg/ATP addition and measured after 40 mins by...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetProto-oncogene tyrosine-protein kinase receptor Ret(Homo sapiens (Human))
Sichuan University/Collaborative Innovation Center Of Biotherapy

Curated by ChEMBL
LigandPNGBDBM50563915(CHEMBL4794949)
Affinity DataIC50:  180nMAssay Description:Inhibition of recombinant human RET V804M mutant using KKKVSRSGLYRSP as substrate incubated for 15 mins followed by Mg/ATP addition and measured afte...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed