BDBM50568727 CHEMBL4867874

SMILES Cc1c(c(c([nH]1)C(=O)Nc2nc3c(cc(cc3s2)C(=O)O)OCCN4CCOCC4)Cl)Cl

InChI Key InChIKey=IALGYKMHQTUZKU-UHFFFAOYSA-N

Data  2 IC50

PDB links: 1 PDB ID matches this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50568727   

TargetDNA gyrase A/A/B/B tetramer(Escherichia coli (strain K12))
University of Ljubljana

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50568727BDBM50568727(CHEMBL4867874)
Affinity DataIC50: 10nMAssay Description:Inhibition of Escherichia coli DNA gyrase assessed as reduction in relaxation of supercoiled pNO1 DNA measured after 30 mins by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2022
Entry Details Article
PubMed
TargetDNA gyrase subunit A/B(Staphylococcus aureus)
University of Ljubljana

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50568727BDBM50568727(CHEMBL4867874)
Affinity DataIC50: 17nMAssay Description:Inhibition of Staphylococcus aureus DNA gyrase assessed reduction in relaxation of supercoiled pNO1 DNA measured after 30 mins by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2022
Entry Details Article
PubMedPDB3D3D Structure (crystal)