BDBM50581525 CHEMBL5088000

SMILES C[C@@H](Nc1ccn2ncc(-c3cnn(CCO)c3)c2n1)c1cc(F)ccc1OCC(F)F

InChI Key InChIKey=GYWAMONQPZXXDB-CYBMUJFWSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50581525   

TargetHigh affinity nerve growth factor receptor(Homo sapiens (Human))
Central China Normal University

Curated by ChEMBL
LigandPNGBDBM50581525(CHEMBL5088000)
Affinity DataIC50:  0.700nMAssay Description:Inhibition of wildtype TRKA (unknown origin) preincubated for 30 mins followed by biotinylated TK-peptide substrate addition and measured after 40 mi...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Central China Normal University

Curated by ChEMBL
LigandPNGBDBM50581525(CHEMBL5088000)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of hERGMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHigh affinity nerve growth factor receptor(Homo sapiens (Human))
Central China Normal University

Curated by ChEMBL
LigandPNGBDBM50581525(CHEMBL5088000)
Affinity DataIC50:  0.5nMAssay Description:Inhibition of TRKA G667C mutant (unknown origin) preincubated for 30 mins followed by biotinylated TK-peptide substrate addition and measured after 4...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHigh affinity nerve growth factor receptor(Homo sapiens (Human))
Central China Normal University

Curated by ChEMBL
LigandPNGBDBM50581525(CHEMBL5088000)
Affinity DataIC50:  0.200nMAssay Description:Inhibition of TRKA GS95R mutant (unknown origin) preincubated for 30 mins followed by biotinylated TK-peptide substrate addition and measured after 4...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed