BDBM50587103 CHEMBL5086113::US20240043470, Compound 2-01-B

SMILES Fc1ccccc1CNC(=O)[C@@H]1Cc2ccc(Oc3cccc(CCC(=O)N[C@@H](CC(=O)N4CCCC4)C(=O)N1)c3)cc2

InChI Key InChIKey=OQWJCQSNKTVANX-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50587103   

TargetProteasome subunit beta type-8(Human)
Cornell University

US Patent
LigandPNGBDBM50587103(CHEMBL5086113 | US20240043470, Compound 2-01-B)
Affinity DataIC50: 845nMAssay Description:Experiments to determine IC50 values against β5i and β5c for compounds were carried out in 96-well plates. In brief, 1 μL of compound ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/12/2024
Entry Details
Go to US Patent

TargetProteasome subunit beta type-8(Human)
Cornell University

US Patent
LigandPNGBDBM50587103(CHEMBL5086113 | US20240043470, Compound 2-01-B)
Affinity DataIC50: 2.11E+4nMAssay Description:Inhibition of human 20S immunoproteasome beta-5i subunit using Suc-LLVY-AMC as substrate measured over 1.5 to 2 hrs by plate reader assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/7/2023
Entry Details Article
PubMed
TargetProteasome subunit beta type-5(Human)
Cornell University

US Patent
LigandPNGBDBM50587103(CHEMBL5086113 | US20240043470, Compound 2-01-B)
Affinity DataIC50: 7.54E+4nMAssay Description:Experiments to determine IC50 values against β5i and β5c for compounds were carried out in 96-well plates. In brief, 1 μL of compound ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/12/2024
Entry Details
Go to US Patent

TargetProteasome subunit beta type-5(Human)
Cornell University

US Patent
LigandPNGBDBM50587103(CHEMBL5086113 | US20240043470, Compound 2-01-B)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of human 20S constitutive proteasome beta-5c subunit using Suc-LLVY-AMC as substrate measured over 1.5 to 2 hrs by plate reader assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/7/2023
Entry Details Article
PubMed