BDBM50587649 CHEMBL5197137

SMILES Cc1c(sc-2c1C(=N[C@H](c3n2c(nn3)C)CC(=O)Nc4ccc(cc4)C(=O)Nc5ccccc5N)c6ccc(cc6)Cl)C

InChI Key InChIKey=GGZYNJKDGRBRKG-UHFFFAOYSA-N

Data  7 IC50  1 Kd

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 11 hits for monomerid = 50587649   

TargetBromodomain-containing protein 4(Human)
Xinxiang Medical University

Curated by ChEMBL
LigandPNGBDBM50587649(CHEMBL5197137)
Affinity DataKd:  69nMAssay Description:Binding affinity to BRD4 BD1 (unknown origin) assessed as dissociation constant by ITC analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
TargetBromodomain-containing protein 4(Human)
Xinxiang Medical University

Curated by ChEMBL
LigandPNGBDBM50587649(CHEMBL5197137)
Affinity DataIC50: 74nMAssay Description:Inhibition of BRD4 BD2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetBromodomain-containing protein 4(Human)
Xinxiang Medical University

Curated by ChEMBL
LigandPNGBDBM50587649(CHEMBL5197137)
Affinity DataIC50: 74nMAssay Description:Inhibition of BRD4-BD2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
TargetBromodomain-containing protein 4(Human)
Xinxiang Medical University

Curated by ChEMBL
LigandPNGBDBM50587649(CHEMBL5197137)
Affinity DataIC50: 74nMAssay Description:Inhibition of BRD4 BD2 (unknown origin) incubated for 30 mins by fluorescence based multimode microtiter plate reader assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
TargetHistone deacetylase 1(Human)
Zhengzhou University

Curated by ChEMBL
LigandPNGBDBM50587649(CHEMBL5197137)
Affinity DataIC50: 290nMAssay Description:Inhibition of full length HDAC1 (unknown origin) by nanoBRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetHistone deacetylase 1(Human)
Zhengzhou University

Curated by ChEMBL
LigandPNGBDBM50587649(CHEMBL5197137)
Affinity DataIC50: 290nMAssay Description:Inhibition of HDAC1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
TargetHistone deacetylase 1(Human)
Zhengzhou University

Curated by ChEMBL
LigandPNGBDBM50587649(CHEMBL5197137)
Affinity DataIC50: 290nMAssay Description:Inhibition of HDAC1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
TargetHistone deacetylase 1(Human)
Zhengzhou University

Curated by ChEMBL
LigandPNGBDBM50587649(CHEMBL5197137)
Affinity DataIC50: 290nMAssay Description:Inhibition of HDAC1 (unknown origin) incubated for 30 mins by fluorescence based multimode microtiter plate reader assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
TargetBromodomain-containing protein 4(Human)
Xinxiang Medical University

Curated by ChEMBL
LigandPNGBDBM50587649(CHEMBL5197137)
Affinity DataIC50: 720nMAssay Description:Inhibition of BRD4 BD1 (unknown origin) incubated for 30 mins by fluorescence based multimode microtiter plate reader assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
TargetBromodomain-containing protein 4(Human)
Xinxiang Medical University

Curated by ChEMBL
LigandPNGBDBM50587649(CHEMBL5197137)
Affinity DataIC50: 720nMAssay Description:Inhibition of BRD4-BD1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
TargetBromodomain-containing protein 4(Human)
Xinxiang Medical University

Curated by ChEMBL
LigandPNGBDBM50587649(CHEMBL5197137)
Affinity DataIC50: 729nMAssay Description:Inhibition of BRD4 BD1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed