BDBM50592246 T3-CLK

SMILES CN1CCN(CC1)C(=O)C(C)(C)c1ccc(cc1)C(=O)Nc1cn2cc(ccc2n1)-c1ccncc1

InChI Key InChIKey=IEFFSHLHNYVSEF-UHFFFAOYSA-N

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 13 hits for monomerid = 50592246   

TargetDual specificity protein kinase CLK1(Human)
University of British Columbia

Curated by ChEMBL
LigandPNGBDBM50592246(T3-CLK)
Affinity DataIC50: 0.670nMAssay Description:Inhibition of CLK1 (unknown origin) using ULight MBP peptide as substrate incubated for 10 mins in presence of ATP incubated for 45 mins by LANCE Ult...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetDual specificity protein kinase CLK1(Human)
University of British Columbia

Curated by ChEMBL
LigandPNGBDBM50592246(T3-CLK)
Affinity DataIC50: 0.670nMAssay Description:Inhibition of N-terminal FLAG-tagged human Clk1 using myelin basic protein as substrate preincubated for 10 mins followed by ATP addition measured af...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMed
TargetDual specificity protein kinase CLK1(Human)
University of British Columbia

Curated by ChEMBL
LigandPNGBDBM50592246(T3-CLK)
Affinity DataIC50: 0.670nMAssay Description:Inhibition of human CLK1More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/20/2024
Entry Details
PubMed
TargetDual specificity protein kinase CLK2(Human)
University of British Columbia

Curated by ChEMBL
LigandPNGBDBM50592246(T3-CLK)
Affinity DataIC50: 0.760nMAssay Description:Inhibition of N-terminal FLAG-tagged human CLK2 using ULight MBP peptide as substrate incubated for 10 mins in presence of 20 uM ATP incubated for 45...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetDual specificity protein kinase CLK2(Human)
University of British Columbia

Curated by ChEMBL
LigandPNGBDBM50592246(T3-CLK)
Affinity DataIC50: 15nMAssay Description:Inhibition of N-terminal FLAG-tagged human CLK2 using ULight MBP peptide as substrate incubated for 10 mins in presence of ATP incubated for 45 mins ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetDual specificity protein kinase CLK2(Human)
University of British Columbia

Curated by ChEMBL
LigandPNGBDBM50592246(T3-CLK)
Affinity DataIC50: 15nMAssay Description:Inhibition of N-terminal FLAG-tagged human Clk2 using myelin basic protein as substrate preincubated for 10 mins followed by ATP addition measured af...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMed
TargetDual specificity protein kinase CLK2(Human)
University of British Columbia

Curated by ChEMBL
LigandPNGBDBM50592246(T3-CLK)
Affinity DataIC50: 15nMAssay Description:Inhibition of N-terminal FLAG-tagged human CLK2 using ULight MBP peptide as substrate incubated for 10 mins in presence of 1 mM ATP incubated for 45 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetDual specificity protein kinase CLK2(Human)
University of British Columbia

Curated by ChEMBL
LigandPNGBDBM50592246(T3-CLK)
Affinity DataIC50: 17nMAssay Description:Inhibition of human CLK2 by NanoBRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/20/2024
Entry Details
PubMed
TargetDual specificity protein kinase CLK3(Homo sapiens)
University of British Columbia

Curated by ChEMBL
LigandPNGBDBM50592246(T3-CLK)
Affinity DataIC50: 110nMAssay Description:Inhibition of CLK3 (unknown origin) using ULight-CREBtide peptide as substrate incubated for 10 mins in presence of ATP incubated for 45 mins by LANC...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetDual specificity protein kinase CLK3(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50592246(T3-CLK)
Affinity DataIC50: 110nMAssay Description:Inhibition of human CLK3More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/20/2024
Entry Details
PubMed
TargetDual specificity tyrosine-phosphorylation-regulated kinase 1B(Human)
University of British Columbia

Curated by ChEMBL
LigandPNGBDBM50592246(T3-CLK)
Affinity DataIC50: 230nMAssay Description:Inhibition of DYRK1B (unknown origin) using ULight-CREBtide peptide as substrate incubated for 10 mins in presence of ATP incubated for 45 mins by LA...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetDual specificity tyrosine-phosphorylation-regulated kinase 1A(Human)
University of British Columbia

Curated by ChEMBL
LigandPNGBDBM50592246(T3-CLK)
Affinity DataIC50: 260nMAssay Description:Inhibition of DYRK1A (unknown origin) using ULight-CREBtide peptide as substrate incubated for 10 mins in presence of ATP incubated for 45 mins by LA...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetDual specificity tyrosine-phosphorylation-regulated kinase 1A(Human)
University of British Columbia

Curated by ChEMBL
LigandPNGBDBM50592246(T3-CLK)
Affinity DataIC50: 260nMAssay Description:Inhibition of N-terminal FLAG-tagged human DYRK1A using myelin basic protein as substrate preincubated for 10 mins followed by ATP addition measured ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMed