BDBM50594795 CHEMBL5205905

SMILES COc1cc(\C=C2/N=C(Nc3ccc(cc3)N3CCNCC3)NC2=O)ccc1O

InChI Key InChIKey=JMMKVTXEDIDGGS-UHFFFAOYSA-N

Data  10 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 10 hits for monomerid = 50594795   

TargetDual specificity protein kinase CLK1(Mouse)
Manros Therapeutics & Perha Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50594795BDBM50594795(CHEMBL5205905)
Affinity DataIC50: 1.20E+3nMAssay Description:Inhibition of GST-fused mouse recombinant CLK1 expressed in Escherichia coli using GRSRSRSRSRSR peptide as substrate incubated for 30 mins in presenc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed
TargetDual specificity protein kinase CLK4(Mouse)
Manros Therapeutics & Perha Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50594795BDBM50594795(CHEMBL5205905)
Affinity DataIC50: 1.20E+3nMAssay Description:Inhibition of GST-fused mouse recombinant CLK4 expressed in Escherichia coli using GRSRSRSRSRSR peptide as substrate incubated for 30 mins in presenc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed
TargetDual specificity tyrosine-phosphorylation-regulated kinase 1A(Human)
Manros Therapeutics & Perha Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50594795BDBM50594795(CHEMBL5205905)
Affinity DataIC50: 1.30E+3nMAssay Description:Inhibition of GST-fused human recombinant DYRK1A expressed in Escherichia coli using GRSRSRSRSRSR peptide as substrate incubated for 30 mins in prese...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed
TargetDual specificity tyrosine-phosphorylation-regulated kinase 3(Human)
Manros Therapeutics & Perha Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50594795BDBM50594795(CHEMBL5205905)
Affinity DataIC50: 1.50E+3nMAssay Description:Inhibition of GST-fused human recombinant DYRK3 expressed in Escherichia coli using GRSRSRSRSRSR peptide as substrate incubated for 30 mins in presen...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed
TargetDual specificity tyrosine-phosphorylation-regulated kinase 2(Human)
Manros Therapeutics & Perha Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50594795BDBM50594795(CHEMBL5205905)
Affinity DataIC50: 2.10E+3nMAssay Description:Inhibition of GST-fused human recombinant DYRK2 expressed in Escherichia coli using GRSRSRSRSRSR peptide as substrate incubated for 30 mins in presen...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed
TargetDual specificity tyrosine-phosphorylation-regulated kinase 1B(Human)
Manros Therapeutics & Perha Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50594795BDBM50594795(CHEMBL5205905)
Affinity DataIC50: 2.20E+3nMAssay Description:Inhibition of GST-fused human recombinant DYRK1B expressed in Escherichia coli using GRSRSRSRSRSR peptide as substrate incubated for 30 mins in prese...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed
TargetDual specificity protein kinase CLK2(Mouse)
Manros Therapeutics & Perha Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50594795BDBM50594795(CHEMBL5205905)
Affinity DataIC50: 3.50E+3nMAssay Description:Inhibition of mouse recombinant GST-fused CLK2 expressed in Escherichia coli using GRSRSRSRSRSR peptide as substrate incubated for 30 mins in presenc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed
TargetGlycogen synthase kinase-3 beta/[Tau protein] kinase(Pig)
Manros Therapeutics & Perha Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50594795BDBM50594795(CHEMBL5205905)
Affinity DataIC50: 6.50E+3nMAssay Description:Inhibition of porcine brain GSK-3alpha/beta using YRRAAVPPSPSLSRHSSPHQpSEDEEE as substrate incubated for 30 mins in presence of ATP by scintillation ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed
TargetSerine/threonine-protein kinase pim-1(Human)
Manros Therapeutics & Perha Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50594795BDBM50594795(CHEMBL5205905)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human recombinant Pim1 expressed in Escherichia coli using histone H1 as substrate incubated for 30 mins in presence of ATP by scintill...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed
TargetDual specificity protein kinase CLK3(Mouse)
Manros Therapeutics & Perha Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50594795BDBM50594795(CHEMBL5205905)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of GST-fused mouse recombinant CLK3 expressed in Escherichia coli using GRSRSRSRSRSR peptide as substrate incubated for 30 mins in presenc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed