BDBM50594804 CHEMBL5179916

SMILES COc1ccc(\C=C2/N=C(Nc3ccccc3)NC2=O)cc1O

InChI Key InChIKey=ZTRPXSAPSNQEEK-UHFFFAOYSA-N

Data  8 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 50594804   

TargetSerine/threonine-protein kinase pim-1(Human)
Manros Therapeutics & Perha Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50594804BDBM50594804(CHEMBL5179916)
Affinity DataIC50: 1.90E+3nMAssay Description:Inhibition of human recombinant Pim1 expressed in Escherichia coli using histone H1 as substrate incubated for 30 mins in presence of ATP by scintill...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed
TargetDual specificity tyrosine-phosphorylation-regulated kinase 1A(Human)
Manros Therapeutics & Perha Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50594804BDBM50594804(CHEMBL5179916)
Affinity DataIC50: 2.00E+3nMAssay Description:Inhibition of GST-fused human recombinant DYRK1A expressed in Escherichia coli using GRSRSRSRSRSR peptide as substrate incubated for 30 mins in prese...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed
TargetDual specificity tyrosine-phosphorylation-regulated kinase 2(Human)
Manros Therapeutics & Perha Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50594804BDBM50594804(CHEMBL5179916)
Affinity DataIC50: 2.10E+3nMAssay Description:Inhibition of GST-fused human recombinant DYRK2 expressed in Escherichia coli using GRSRSRSRSRSR peptide as substrate incubated for 30 mins in presen...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed
TargetDual specificity tyrosine-phosphorylation-regulated kinase 3(Human)
Manros Therapeutics & Perha Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50594804BDBM50594804(CHEMBL5179916)
Affinity DataIC50: 2.40E+3nMAssay Description:Inhibition of GST-fused human recombinant DYRK3 expressed in Escherichia coli using GRSRSRSRSRSR peptide as substrate incubated for 30 mins in presen...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed
TargetDual specificity tyrosine-phosphorylation-regulated kinase 1B(Human)
Manros Therapeutics & Perha Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50594804BDBM50594804(CHEMBL5179916)
Affinity DataIC50: 2.80E+3nMAssay Description:Inhibition of GST-fused human recombinant DYRK1B expressed in Escherichia coli using GRSRSRSRSRSR peptide as substrate incubated for 30 mins in prese...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed
TargetDual specificity protein kinase CLK4(Mouse)
Manros Therapeutics & Perha Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50594804BDBM50594804(CHEMBL5179916)
Affinity DataIC50: 4.00E+3nMAssay Description:Inhibition of GST-fused mouse recombinant CLK4 expressed in Escherichia coli using GRSRSRSRSRSR peptide as substrate incubated for 30 mins in presenc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed
TargetDual specificity protein kinase CLK1(Mouse)
Manros Therapeutics & Perha Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50594804BDBM50594804(CHEMBL5179916)
Affinity DataIC50: 4.30E+3nMAssay Description:Inhibition of GST-fused mouse recombinant CLK1 expressed in Escherichia coli using GRSRSRSRSRSR peptide as substrate incubated for 30 mins in presenc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed
TargetCasein kinase II subunit alpha 3(Human)
Manros Therapeutics & Perha Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50594804BDBM50594804(CHEMBL5179916)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human recombinant CK2 using RRRDDDSDDD peptide as substrate incubated for 30 mins in presence of ATP by scintillation counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed