BDBM50597714 AG-348::Ag-348::MITAPIVAT::Mitapivat::Pkr-in-1::US20250051313, Compound Mitapivat

SMILES c1cc2cccnc2c(c1)S(=O)(=O)Nc3ccc(cc3)C(=O)N4CCN(CC4)CC5CC5

InChI Key InChIKey=XAYGBKHKBBXDAK-UHFFFAOYSA-N

Data  1 IC50  4 EC50

PDB links: 1 PDB ID matches this monomer.

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50597714   

TargetPyruvate kinase PKM(Human)
Children's Hospital Affiliated to Zhengzhou University

Curated by ChEMBL
LigandPNGBDBM50597714(Mitapivat | Ag-348 | Pkr-in-1 | AG-348 | MITAPIVAT...)
Affinity DataIC50: 20nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetPyruvate kinase PKM(Human)
Children's Hospital Affiliated to Zhengzhou University

Curated by ChEMBL
LigandPNGBDBM50597714(Mitapivat | Ag-348 | Pkr-in-1 | AG-348 | MITAPIVAT...)
Affinity DataEC50:  20nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetPyruvate kinase PKLR(Human)
Sitryx Therapeutics

US Patent
LigandPNGBDBM50597714(Mitapivat | Ag-348 | Pkr-in-1 | AG-348 | MITAPIVAT...)
Affinity DataEC50:  32.1nMAssay Description:Human PKLR was diluted into Assay Buffer to a final concentration of 5 pM. Enzyme-Assay Buffer mix was dispensed into 384-well shallow-well white-wal...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/17/2025
Entry Details
Go to US Patent
PDB3D3D Structure (crystal)
TargetPyruvate kinase PKM(Human)
Children's Hospital Affiliated to Zhengzhou University

Curated by ChEMBL
LigandPNGBDBM50597714(Mitapivat | Ag-348 | Pkr-in-1 | AG-348 | MITAPIVAT...)
Affinity DataEC50:  37nMAssay Description:Activation of PKM2 (unknown origin) Lys311, Asp354, Met30, Phe26 residuesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed
TargetPyruvate kinase PKM(Human)
Children's Hospital Affiliated to Zhengzhou University

Curated by ChEMBL
LigandPNGBDBM50597714(Mitapivat | Ag-348 | Pkr-in-1 | AG-348 | MITAPIVAT...)
Affinity DataEC50:  321nMAssay Description:Human PKM2 was diluted into Assay Buffer comprising 50 mM imidazole, 50 mM KCl, 7 mM MgCl2, 0.01% Tween20, 0.05% BSA (pH 7.2) to a final concentratio...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/17/2025
Entry Details
Go to US Patent