BDBM50598859 CHEMBL5200945

SMILES c1cc(ccc1CN(C2CC2)C(=O)c3ccc4c(c3)OCC(=O)N4)C(=O)Nc5ccncn5

InChI Key InChIKey=KOZGEDUWAQFVAV-UHFFFAOYSA-N

Data  1 IC50  6 Kd

PDB links: 1 PDB ID matches this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 15 hits for monomerid = 50598859   

LigandPNGBDBM50598859(CHEMBL5200945)
Affinity DataIC50: 1.20nMAssay Description:Inhibition of NSD2 PWWP1 domain (unknown origin) by NanoBRET target engagement assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details PDB3D3D Structure (crystal)
LigandPNGBDBM50598859(CHEMBL5200945)
Affinity DataKd:  10nMAssay Description:Binding affinity to NSD2 PWWP1 domain (unknown origin) assessed as dissociation constant by SPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMedPDB3D3D Structure (crystal)
LigandPNGBDBM50598859(CHEMBL5200945)
Affinity DataKd:  91nMAssay Description:Binding affinity to NSD2 PWWP1 domain (unknown origin) assessed as dissociation constant by SPR analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2024
Entry Details
PubMedPDB3D3D Structure (crystal)
LigandPNGBDBM50598859(CHEMBL5200945)
Affinity DataKd:  91nMAssay Description:Binding affinity to NSD2 PWWP1 domain (unknown origin) assessed as dissociation constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMedPDB3D3D Structure (crystal)
LigandPNGBDBM50598859(CHEMBL5200945)
Affinity DataKd:  91nMAssay Description:Binding affinity to NSD2 (unknown origin) assessed as dissociation constant by SPR analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details PDB3D3D Structure (crystal)
LigandPNGBDBM50598859(CHEMBL5200945)
Affinity DataKd:  91nMAssay Description:Binding affinity to NSD2 (unknown origin) assessed as dissociation constant by SPR analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details PDB3D3D Structure (crystal)
LigandPNGBDBM50598859(CHEMBL5200945)
Affinity DataKd:  91nMAssay Description:Binding affinity to NSD2 PWWP1 domain (unknown origin) assessed as dissociation constant by SPR analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details PDB3D3D Structure (crystal)
LigandPNGBDBM50598859(CHEMBL5200945)
Affinity DataKd:  91nMAssay Description:Binding affinity to NSD2 PWWP1 domain (unknown origin) assessed as dissociation constant by SPR analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details PDB3D3D Structure (crystal)
LigandPNGBDBM50598859(CHEMBL5200945)
Affinity DataKd:  91nMAssay Description:Binding affinity to biotinylated human NSD2 PWWP1 domain (208 to 368 residues) expressed in Escherichia coli BL2I (DE3) cells assessed as dissociatio...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2023
Entry Details
PubMedPDB3D3D Structure (crystal)
LigandPNGBDBM50598859(CHEMBL5200945)
Affinity DataKd:  91nMAssay Description:Binding affinity to human biotinylated NSD2 (208 to 368 residues) expressed in Escherichia coli BL21(DE3) by SPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2024
Entry Details
PubMedPDB3D3D Structure (crystal)
LigandPNGBDBM50598859(CHEMBL5200945)
Affinity DataIC50: 104nMAssay Description:Inhibition of NSD2 PWWP1 domain (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2024
Entry Details
PubMedPDB3D3D Structure (crystal)
LigandPNGBDBM50598859(CHEMBL5200945)
Affinity DataIC50: 104nMAssay Description:Inhibition of NSD2 PWWP1 domain (unknown origin) by alphascreen assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details PDB3D3D Structure (crystal)
LigandPNGBDBM50598859(CHEMBL5200945)
Affinity DataIC50: 104nMAssay Description:Inhibition of NSD2 PWWP1 domain (unknown origin) by Alphascreen assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details PDB3D3D Structure (crystal)
LigandPNGBDBM50598859(CHEMBL5200945)
Affinity DataKd:  500nMAssay Description:Binding affinity to N-terminal GST-tagged human NSD2 PWWP1 domain (208 to 369 residues) expressed in Escherichia coli BL2I (DE3) cells assessed as di...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2023
Entry Details
PubMedPDB3D3D Structure (crystal)
LigandPNGBDBM50598859(CHEMBL5200945)
Affinity DataIC50: 9.10E+4nMAssay Description:Binding affinity to biotinylated human NSD2 PWWP1 domain (208 to 368 residues) expressed in Escherichia coli BL21(DE3) assessed as dissociation const...More data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details PDB3D3D Structure (crystal)