BDBM50598880 CHEMBL5187248

SMILES Cc1ccc2n(Cc3ccc(Cl)cc3)c(cc2c1)[C@H]1C[C@@H](CN1C(=O)c1cnc2[nH]ccc2c1)n1ccnc1CN

InChI Key InChIKey=IRMSFVCDJOZKRF-LITSAYRRSA-N

Data  3 IC50

PDB links: 1 PDB ID matches this monomer.

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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50598880   

TargetIndolethylamine N-methyltransferase(Human)
Shionogi

Curated by ChEMBL
LigandPNGBDBM50598880(CHEMBL5187248)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of N-terminal 6His-tagged full length human recombinant INMT (1 to 263 residues) expressed in Escherichia coli BL21 (DE3) cells using S-(5...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In DepthDetails PubMed
TargetNicotinamide N-methyltransferase(Human)
Shionogi

Curated by ChEMBL
LigandPNGBDBM50598880(CHEMBL5187248)
Affinity DataIC50:  5.50E+3nMAssay Description:Inhibition of NNMT in HEK293 cells measured after 20 to 24 hrs by RapidFire Mass SpectrometryMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
TargetNicotinamide N-methyltransferase(Human)
Shionogi

Curated by ChEMBL
LigandPNGBDBM50598880(CHEMBL5187248)
Affinity DataIC50:  16nMAssay Description:Inhibition of N-terminal 6His-tagged full length human recombinant NNMT (1 to 264 residues) expressed in Escherichia coli BL21 (DE3) cells using S-ad...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB