BDBM50609301 CHEMBL4559961

SMILES CNCCN1CCC(CC1)c2cc(ccn2)CN(C)C(=O)c3cccc(c3)Oc4ccccc4

InChI Key InChIKey=VUIITYLFSAXKIQ-UHFFFAOYSA-N

Data  1 IC50

PDB links: 1 PDB ID matches this monomer.

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 50609301   

TargetHistone-arginine methyltransferase CARM1(Human)
Shanghai Institute of Materia Medica

Curated by ChEMBL
LigandPNGBDBM50609301(CHEMBL4559961)
Affinity DataIC50: 10nMAssay Description:Inhibition of FLAG-tagged CARM1 (unknown origin) (2 to 585 residues) using biotin-aminohexanoate-PRKQLATKAARMeKSAP-amide peptide as substrate preincu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/20/2024
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetHistone-arginine methyltransferase CARM1(Human)
Shanghai Institute of Materia Medica

Curated by ChEMBL
LigandPNGBDBM50609301(CHEMBL4559961)
Affinity DataIC50: 10nMAssay Description:Inhibition of CARM1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details PDB3D3D Structure (crystal)
TargetHistone-arginine methyltransferase CARM1(Human)
Shanghai Institute of Materia Medica

Curated by ChEMBL
LigandPNGBDBM50609301(CHEMBL4559961)
Affinity DataIC50: 10nMAssay Description:Inhibition of human PRMT4 (1 to 608 residues) methyltransferase activity using biotinylated peptide as substrate and SAM as cofactor incubated for 30...More data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details PDB3D3D Structure (crystal)
TargetHistone-arginine methyltransferase CARM1(Human)
Shanghai Institute of Materia Medica

Curated by ChEMBL
LigandPNGBDBM50609301(CHEMBL4559961)
Affinity DataIC50: 10nMAssay Description:Inhibition of PRMT4 (unknown origin) using biotinylated peptide substrate in presence of SAM by scintillation proximity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details PDB3D3D Structure (crystal)
TargetHistone-arginine methyltransferase CARM1(Human)
Shanghai Institute of Materia Medica

Curated by ChEMBL
LigandPNGBDBM50609301(CHEMBL4559961)
Affinity DataIC50: 43nMAssay Description:Inhibition of PRMT4 in HEK293 cells assessed as reduction in MED12 methylationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details PDB3D3D Structure (crystal)
TargetHistone-arginine methyltransferase CARM1(Human)
Shanghai Institute of Materia Medica

Curated by ChEMBL
LigandPNGBDBM50609301(CHEMBL4559961)
Affinity DataIC50: 181nMAssay Description:Inhibition of PRMT4 in human MDA-MB-231 cells assessed as decrease in BAF155 methylation level incubated for 48 hrs by Western blot analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details PDB3D3D Structure (crystal)
TargetHistone-arginine methyltransferase CARM1(Human)
Shanghai Institute of Materia Medica

Curated by ChEMBL
LigandPNGBDBM50609301(CHEMBL4559961)
Affinity DataIC50: 340nMAssay Description:Inhibition of PRMT4 in HEK293 cells assessed as reduction in BAF155 methylationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details PDB3D3D Structure (crystal)
LigandPNGBDBM50609301(CHEMBL4559961)
Affinity DataIC50: 1.30E+3nMAssay Description:Inhibition of PRMT6 (unknown origin) using biotinylated peptide substrate in presence of SAM by scintillation proximity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details