BDBM50613160 CHEMBL5279012

SMILES Cc1c2c([nH]c1C(=O)N[C@@H](CCC3CC3)C(=O)Nc4ccc(cc4)C#N)CC(CC2=O)(C)C

InChI Key InChIKey=OWORSODZTADOQX-UHFFFAOYSA-N

Data  3 IC50  1 Kd

PDB links: 1 PDB ID matches this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50613160   

TargetHistone-lysine N-methyltransferase EHMT2(Human)
Kyorin Pharmaceutical Co. Ltd.

Curated by ChEMBL
LigandPNGBDBM50613160(CHEMBL5279012)
Affinity DataIC50: 27nMAssay Description:Inhibition of G9a (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetHistone-lysine N-methyltransferase EHMT2(Human)
Kyorin Pharmaceutical Co. Ltd.

Curated by ChEMBL
LigandPNGBDBM50613160(CHEMBL5279012)
Affinity DataIC50: 27nMAssay Description:Inhibition of N-terminal GST-tagged human recombinant G9a (785 to 1210 residues) expressed in baculovirus infected Sf9 cells incubated for 1 hr by Al...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/22/2024
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetHistone-lysine N-methyltransferase EHMT2(Human)
Kyorin Pharmaceutical Co. Ltd.

Curated by ChEMBL
LigandPNGBDBM50613160(CHEMBL5279012)
Affinity DataIC50: 27nMAssay Description:Inhibition of N-terminal GST-tagged human recombinant G9a (785 to 1210 residues) expressed in baculovirus infected Sf9 cells incubated for 1 hr by Al...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/22/2024
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetHistone-lysine N-methyltransferase EHMT2(Human)
Kyorin Pharmaceutical Co. Ltd.

Curated by ChEMBL
LigandPNGBDBM50613160(CHEMBL5279012)
Affinity DataKd:  750nMAssay Description:Binding affinity to G9a (unknown origin) assessed as dissociation constant by SPR analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMedPDB3D3D Structure (crystal)