BDBM50616544 MK-8189::Mk-8189

SMILES Cc1ccc(nc1)[C@H]2C[C@@H]2COc3cc(nc(n3)C)NCc4nnc(s4)C

InChI Key InChIKey=WQKPZDLZRFTMTI-UHFFFAOYSA-N

Data  1 KI  7 IC50  1 EC50

PDB links: 1 PDB ID matches this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 9 hits for monomerid = 50616544   

LigandPNGBDBM50616544(MK-8189 | Mk-8189)
Affinity DataKi:  0.0290nMAssay Description:Inhibition of human PDE10A2 transfected in human AD293 cells cytosolic fraction using cAMP as substrate by fluorescence polarization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2024
Entry Details
PubMedPDB3D3D Structure (crystal)
LigandPNGBDBM50616544(MK-8189 | Mk-8189)
Affinity DataIC50: 1.60nMAssay Description:Inhibition of human recombinant full length PDE10AMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2024
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetSomatostatin receptor type 2(Human)
Merck

Curated by ChEMBL
LigandPNGBDBM50616544(MK-8189 | Mk-8189)
Affinity DataIC50: 2.80E+3nMAssay Description:Displacement of [125I]somatostatin from human full-length recombinant SSTR2 expressed in CHO-K1 cells by radioligand binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2024
Entry Details
PubMed
LigandPNGBDBM50616544(MK-8189 | Mk-8189)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of Cav1.2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2024
Entry Details
PubMed
LigandPNGBDBM50616544(MK-8189 | Mk-8189)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of Nav1.5 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2024
Entry Details
PubMed
LigandPNGBDBM50616544(MK-8189 | Mk-8189)
Affinity DataEC50: >3.00E+4nMAssay Description:Activation of PXR (unknown origin) assessed as CYP3A4 inductionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2024
Entry Details
PubMed
LigandPNGBDBM50616544(MK-8189 | Mk-8189)
Affinity DataIC50: 3.30E+4nMAssay Description:Displacement of MK499 from hERGMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2024
Entry Details
PubMed
TargetCytochrome P450 3A4(Human)
Merck

Curated by ChEMBL
LigandPNGBDBM50616544(MK-8189 | Mk-8189)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of CYP3A4 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2024
Entry Details
PubMed
TargetCytochrome P450 2C9(Human)
Merck

Curated by ChEMBL
LigandPNGBDBM50616544(MK-8189 | Mk-8189)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of CYP2C9 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2024
Entry Details
PubMed