BDBM506220 (S)-6-(((2-(2,2-difluoroethyl)-1-oxo-1,2- dihydroisoquinolin-5-yl)(1-(1- (difluoromethyl)cyclopropyl)-1H-1,2,3-triazol- 4-yl)methyl)amino)-4- (neopentylamino)quinoline- 3,8-dicarbonitrile::US11066414, Compound 870

SMILES CC(C)(C)CNc1c(cnc2c(cc(N[C@H](C3=CN(NN3)C3(CC3)C(F)F)c3cccc4c3ccn(CC(F)F)c4=O)cc12)C#N)C#N

InChI Key InChIKey=JUUJJAKAHVAPKI-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 506220   

TargetEpidermal growth factor receptor(Human)
Gilead Sciences

US Patent
LigandPNGBDBM506220(US11066414, Compound 870 | (S)-6-(((2-(2,2-difluor...)
Affinity DataIC50: 2nMAssay Description:EGFR activity was measured using KinEASE (Cisbio), a time-resolved fluorescence resonance energy transfer (TR-FRET) immunoassay. In this assay, EGFR-...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/23/2021
Entry Details
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