BDBM50636132 CHEMBL5558986

SMILES COc1cc(cc(c1)OC)N2Cc3cnc(nc3N(C2=O)CCc4ccc(cc4)NC(=O)C=C)Nc5ccccc5NC(=O)C=C

InChI Key InChIKey=NOZQNRBLSPCZJQ-UHFFFAOYSA-N

PDB links: 2 PDB IDs match this monomer.

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50636132   

TargetFibroblast growth factor receptor 4(Human)
Central South University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50636132BDBM50636132(CHEMBL5558986)
Affinity DataIC50: 7nMAssay Description:Inhibition of human FGFR4 (445 to 753 residues) using preincubated for 30 mins followed by ATP plus poly (4:1 glu, tyr) addition and measured after 3...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetFibroblast growth factor receptor 4(Human)
Central South University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50636132BDBM50636132(CHEMBL5558986)
Affinity DataIC50: 29nMAssay Description:Inhibition of human FGFR4 C477A mutant using preincubated for 30 mins followed by ATP plus poly (4:1 glu, tyr) addition and measured after 30 mins by...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetFibroblast growth factor receptor 4(Human)
Central South University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50636132BDBM50636132(CHEMBL5558986)
Affinity DataIC50: 113nMAssay Description:Inhibition of human FGFR4 C552A mutant using preincubated for 30 mins followed by ATP plus poly (4:1 glu, tyr) addition and measured after 30 mins by...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetFibroblast growth factor receptor 2(Human)
Central South University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50636132BDBM50636132(CHEMBL5558986)
Affinity DataIC50: 150nMAssay Description:Inhibition of human FGFR2 (458 to 768 residues) using preincubated for 30 mins followed by ATP plus poly (4:1 glu, tyr) addition and measured after 3...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetFibroblast growth factor receptor 3(Human)
Central South University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50636132BDBM50636132(CHEMBL5558986)
Affinity DataIC50: 201nMAssay Description:Inhibition of human FGFR3 (450 to 758 residues) using preincubated for 30 mins followed by ATP plus poly (4:1 glu, tyr) addition and measured after 3...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetFibroblast growth factor receptor 1(Human)
Central South University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50636132BDBM50636132(CHEMBL5558986)
Affinity DataIC50: 420nMAssay Description:Inhibition of human FGFR1 (456 to 765 residues) using preincubated for 30 mins followed by ATP plus poly (4:1 glu, tyr) addition and measured after 3...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMedPDB3D3D Structure (crystal)